Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 16/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9318010 | 0.90 | KDM4E (0.50) | MDM2ITGB3ITGA2BKDM4EALOX15 | |
| SCHEMBL9319073 | 0.87 | MDM2 (0.41) | MDM2ITGB3ITGA2BTP53KDM4E | |
| SCHEMBL7326762 | 0.86 | AGTR1 (0.39) | MDM2TP53KDM4ETSHRAGTR1 | |
| SCHEMBL7332495 | 0.78 | ALDH1A1 (0.40) | ITGB3ITGA2BKDM4EALOX15TSHR | |
| Trifluoroacetic Acid SCHEMBL7331122 | 0.77 | ITGB3 (0.37) | MDM2ITGB3ITGA2BKDM4EALOX15 | |
| Trifluoroacetic Acid SCHEMBL7333020 | 0.77 | ITGB3 (0.37) | MDM2ITGB3ITGA2BKDM4EALOX15 | |
| SCHEMBL7329007 | 0.75 | ALDH1A1 (0.37) | KDM4E | |
| SCHEMBL8959460 | 0.74 | KDM4E (0.47) | MDM2ITGB3ITGA2BTP53KDM4E | |
| SCHEMBL11692626 | 0.74 | KMT2A (0.50) | KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL7332551 | 0.74 | PPARD (0.41) | MDM2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | disclosed |