Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.58 |
| ▸ | RXRB | P28702 | 9/20 | 0.58 |
| ▸ | RXRG | P48443 | 9/20 | 0.58 |
| ▸ | RARB | P10826 | 7/20 | 0.58 |
| ▸ | RARG | P13631 | 7/20 | 0.58 |
| ▸ | RARA | P10276 | 6/20 | 0.58 |
| ▸ | PPARG | P37231 | 2/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6664628 | 0.86 | CYP3A4 (0.71) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9268128 | 0.85 | RARA (0.62) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL24410706 | 0.85 | CYP3A4 (0.56) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL24410726 | 0.84 | RXRA (0.53) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL5084210 | 0.82 | CYP3A4 (0.72) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7669063 | 0.82 | RXRA (0.54) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL6880222 | 0.82 | RXRA (0.54) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8890100 | 0.82 | CYP3A4 (0.52) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8891765 | 0.82 | CYP3A4 (0.46) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9483542 | 0.81 | RARB (0.71) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0284261-B1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN INC (US) | 1994-01-05 | — | — | EP | claimed |
| EP-0284261-A1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN, INC (US) | 1988-09-28 | — | — | EP | claimed |
| US-20220144783-A1 | SYNTHETIC RETINOIDS FOR USE IN RAR ACTIVATION | UNIVERSITY OF DURHAM (GB) | 2022-05-12 | — | — | US | disclosed |
| EP-0284261-B1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN INC (US) | 1994-01-05 | — | — | EP | disclosed |
| EP-0284261-A1 | Acetylenes disubstituted with a heteroaromatic group and a tetralin group having retinoid like activity | ALLERGAN, INC (US) | 1988-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144783-A1 | SYNTHETIC RETINOIDS FOR USE IN RAR ACTIVATION | RARA, RXRA, RARB | RXRA 2/4885RXRB 5/4885RXRG 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.