Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 3/20 | 0.60 |
| ▸ | DRD3 | P35462 | 3/20 | 0.60 |
| ▸ | HTR3A | P46098 | 3/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.60 |
| ▸ | HTR3B | O95264 | 1/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780407 | 0.99 | HTR1A (0.59) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL9319475 | 0.95 | HTR1A (0.62) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL6927912 | 0.91 | HTR1A (0.64) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| Hydrochloric Acid SCHEMBL7302055 | 0.90 | LMNA (0.65) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL27683904 | 0.85 | DRD2 (0.61) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL7524534 | 0.84 | HTR1A (0.68) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL255189 | 0.84 | HTR1A (0.68) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL7081828 | 0.84 | HTR1A (0.59) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| Hydrochloric Acid SCHEMBL787250 | 0.83 | MAPT (0.69) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 | |
| Hydrochloric Acid SCHEMBL16528267 | 0.83 | MAPT (0.69) | HTR1ASLC6A2SLC6A4SLC6A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4210646-A | ANTIFUNGAL, ANTIBACTERIAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-07-01 | — | — | US | claimed |
| EP-0364350-B1 | 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl] thiazole derivatives, their preparation and pharmaceutical compositions containing them | INST RECH CHIM BIOLOG (FR) | 1994-01-12 | — | — | EP | disclosed |
| US-5120736-A | Treatment of functional dysuria associated with hyperactivity of adrenergic smypathetic nervous system | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (FR) | 1992-06-09 | — | — | US | disclosed |
| WO-1990003972-A1 | DERIVATIVES OF METAL-4 ((PHENYL-4 PIPERAZINYL-1)-2 ETHYL))-5 THIAZOLE | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (I.R.C.E.B.A.) (FR) | 1990-04-19 | — | — | WO | disclosed |
| EP-0364350-A1 | 4-Methyl-5[2-(4-phenyl-1-piperazinyl)-ethyl] thiazole derivatives, their preparation and pharmaceutical compositions containing them | INSTITUT DE RECHERCHES CHIMIQUES ET BIOLOGIQUES APPLIQUEES (IRCEBA) (FR) | 1990-04-18 | — | — | EP | disclosed |
| US-4335126-A | SEDATIVES, TRANQUILIZERS, AND ANTIPYRETICS; NEUROLEPTIC AND ANTIEDEMIC AGENTS | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1982-06-15 | — | — | US | disclosed |
| US-4210646-A | ANTIFUNGAL, ANTIBACTERIAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-07-01 | — | — | US | disclosed |
| US-4210646-A | ANTIFUNGAL, ANTIBACTERIAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-07-01 | — | — | US | disclosed |
| US-4210646-A | ANTIFUNGAL, ANTIBACTERIAL | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-07-01 | — | — | US | disclosed |