Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.49 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.49 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.49 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.49 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.49 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9426416 | 0.88 | THRB (0.58) | DRD2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL9320513 | 0.86 | LMNA (0.59) | LMNADRD2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL9568368 | 0.83 | LMNA (0.58) | LMNADRD2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL9514633 | 0.79 | LMNA (0.80) | LMNATHRBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL15289999 | 0.79 | KMT2A (0.57) | SMN1; SMN2KMT2AMEN1EPHX2PRMT5 | |
| SCHEMBL9319914 | 0.79 | LMNA (0.51) | LMNATHRBSMN1; SMN2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL9513006 | 0.78 | LMNA (0.78) | LMNATHRBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9513026 | 0.78 | WNK1 (0.64) | LMNADRD2THRBSMN1; SMN2KMT2A | |
| SCHEMBL9320378 | 0.78 | LMNA (0.52) | LMNATHRBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9321264 | 0.78 | LMNA (0.54) | LMNAPRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286728-A | Amino-substituted piperazine derivatives | CIBA-GEIGY CORPORATION (US) | 1994-02-15 | — | — | US | disclosed |
| EP-0524146-A1 | Aminosubstituted Piperazinederivatives | CIBA-GEIGY AG (CH) | 1993-01-20 | — | — | EP | disclosed |