SCHEMBL932151

SCHEMBL932151

CCC1(c2cccc(Br)c2)N=C(C)C(O)=N1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA1 P02708 1/20 0.35
CHRNG P07510 1/20 0.35
CHRNB1 P11230 1/20 0.35
CHRNB2 P17787 1/20 0.35
SLC6A2 P23975 1/20 0.35
CHRNB4 P30926 1/20 0.35
SLC6A4 P31645 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA4 P43681 1/20 0.35
SLC6A3 Q01959 1/20 0.35
CHRND Q07001 1/20 0.35
ALDH1A1 P00352 3/20 0.35
MAPK1 P28482 1/20 0.35
NPSR1 Q6W5P4 2/20 0.33
HCAR3 P49019 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
TSHR P16473 1/20 0.33
KDM1A O60341 1/20 0.33
RCOR1 Q9UKL0 1/20 0.33
GAA P10253 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL932309 0.82 BACE1 (0.44) ALDH1A1MAPK1KDM1ARCOR1CTSD
SCHEMBL931186 0.78 CHRNA1 (0.40) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL932806 0.76 BACE1 (0.41) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL932827 0.72 BACE1 (0.44) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL932777 0.66 BACE1 (0.65) NPSR1CTSDBACE1SMN1; SMN2LMNA
SCHEMBL8204686 0.65 ALDH1A1 (0.39) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL8402532 0.65 KDM1A (0.41) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL945358 0.62 BACE1 (0.58) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL3280576 0.61 CHRNA1 (0.41) CHRNA1CHRNGCHRNB1CHRNB2SLC6A2
SCHEMBL14004410 0.61 ALDH1A1 (0.48) SLC6A2SLC6A4SLC6A3ALDH1A1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011002408-A1 NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA ASTRAZENECA AB (SE) 2011-01-06 WO disclosed
WO-2011002408-A1 NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA ASTRAZENECA AB (SE) 2011-01-06 WO disclosed