Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.43 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13897218 | 0.81 | HTR1A (0.41) | LTA4HLMNA | |
| SCHEMBL3167046 | 0.79 | USP2 (0.30) | — | |
| SCHEMBL14922326 | 0.73 | HRH3 (0.47) | ESR2MEN1KMT2A | |
| SCHEMBL14922258 | 0.72 | ADRB1 (0.53) | LTA4H | |
| SCHEMBL8759961 | 0.72 | ESR1 (0.42) | PTGS1SLC6A2LMNACYP2C19PTGS2 | |
| SCHEMBL11793991 | 0.71 | DRD2 (0.37) | — | |
| SCHEMBL6694113 | 0.71 | HPGD (0.47) | LTA4HSLC6A2LMNACYP1A2SLC6A3 | |
| SCHEMBL7720231 | 0.70 | PKM (0.51) | LTA4HLMNAKMT2A | |
| SCHEMBL3154815 | 0.70 | — | — | |
| SCHEMBL26554537 | 0.69 | ESR2 (0.38) | LTA4HNR5A1PTGS1SLC6A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0427480-B1 | 2-Hydroxy-3-phenoxypropylamino compounds | ICI PLC (GB) | 1994-01-12 | — | — | EP | disclosed |
| US-5187190-A | PHENOXYPROPANOLAMINE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-02-16 | — | — | US | disclosed |
| EP-0427480-A1 | 2-Hydroxy-3-phenoxypropylamino compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-05-15 | — | — | EP | disclosed |