SCHEMBL932277

SCHEMBL932277

COc1ccc(-c2nc(C#N)n(S(=O)(=O)N(C)C)c2Cl)cc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 3/20 0.39
CXCR2 P25025 1/20 0.35
KDM4E B2RXH2 4/20 0.35
MAPT P10636 2/20 0.35
CRHR1 P34998 1/20 0.35
USP8 P40818 1/20 0.34
USP7 Q93009 1/20 0.34
TSHR P16473 2/20 0.34
LMNA P02545 1/20 0.34
HTT P42858 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
MAPK1 P28482 1/20 0.34
CASP1 P29466 1/20 0.34
HSD17B10 Q99714 1/20 0.34
ACLY P53396 1/20 0.34
SRC P12931 2/20 0.34
ALDH3A1 P30838 1/20 0.34
PTGS1 P23219 1/20 0.33
PDGFRB P09619 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1073894 0.85 PTGS2 (0.46) PTGS2KDM4EMAPTCRHR1TSHR
SCHEMBL933896 0.84 ADORA1 (0.42) KDM4EMAPTUSP8TSHRLMNA
SCHEMBL932694 0.82 KMT2A (0.38) PTGS2KDM4EMAPTUSP8USP7
SCHEMBL9520829 0.81 PTGS2 (0.39) PTGS2KDM4EMAPTTSHRLMNA
SCHEMBL9323989 0.78 TSHR (0.49) KDM4ETSHRLMNAHTTALDH1A1
SCHEMBL933331 0.77 TSHR (0.34) PTGS2MAPTTSHRLMNAHPGD
SCHEMBL1074589 0.72 PTGS1 (0.41) PTGS2KDM4EMAPTTSHRLMNA
SCHEMBL9519745 0.69 SMN1; SMN2 (0.33) KDM4E
SCHEMBL4858808 0.68 CYP1A2 (0.36) KDM4EMAPTUSP8USP7LMNA
Cyazofamid SCHEMBL16180421 0.68 PTGS2 (0.38) PTGS2KDM4ETSHRHTTPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2451275-A1 AGRICULTURAL OR HORTICULTURAL FUNGICIDE COMPOSITION AND ITS USE FOR CONTROLLING PLANT PATHOGENS Ishihara Sangyo Kaisha, Ltd. (JP) 2012-05-16 EP disclosed
WO-2011004901-A1 AGRICULTURAL OR HORTICULTURAL FUNGICIDE COMPOSITION AND ITS USE FOR CONTROLLING PLANT PATHOGENS ISHIHARA SANGYO KAISHA, LTD. (JP) 2011-01-13 WO disclosed
EP-1316254-A1 Pesticidal composition and method for controlling pests ISHIHARA SANGYO KAISHA, LTD. (JP) 2003-06-04 EP disclosed
EP-1194039-A2 PESTICIDAL COMPOSITION AND METHOD FOR CONTROLLING PESTS ISHIHARA SANGYO KAISHA, LTD. (JP) 2002-04-10 EP disclosed
WO-2001005231-A2 PESTICIDAL COMPOSITION AND METHOD FOR CONTROLLING PESTS ISHIHARA SANGYO KAISHA, LTD. (JP) 2001-01-25 WO disclosed
EP-0979034-A1 COMPOSITION FOR CONTROLLING HARMFUL BIO-ORGANISMS AND METHOD FOR CONTROLLING HARMFUL BIO-ORGANISMS USING THE SAME ISHIHARA SANGYO KAISHA, LTD. (JP) 2000-02-16 EP disclosed
WO-1998048628-A1 COMPOSITION FOR CONTROLLING HARMFUL BIO-ORGANISMS AND METHOD FOR CONTROLLING HARMFUL BIO-ORGANISMS USING THE SAME ISHIHARA SANGYO KAISHA, LTD. (JP) 1998-11-05 WO disclosed