SCHEMBL1074589

SCHEMBL1074589

COc1ccc(-c2c(Cl)nc(C#N)n2S(=O)(=O)N(C)C)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.41
PTGS2 P35354 1/20 0.41
KDM4E B2RXH2 8/20 0.40
ALDH1A1 P00352 9/20 0.38
HPGD P15428 6/20 0.38
MAOA P21397 3/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 2/20 0.38
GABRA1 P14867 1/20 0.37
GABRG2 P18507 1/20 0.37
GABRB3 P28472 1/20 0.37
GABRA3 P34903 1/20 0.37
GABRA2 P47869 1/20 0.37
MAPT P10636 3/20 0.36
LMNA P02545 2/20 0.36
TSHR P16473 2/20 0.36
HTT P42858 2/20 0.36
NPC1 O15118 1/20 0.36
OPRK1 P41145 1/20 0.36
RAB9A P51151 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9519740 0.88 PTGS2 (0.39) PTGS1PTGS2KDM4EALDH1A1HPGD
Cyazofamid SCHEMBL16180421 0.86 PTGS2 (0.38) PTGS1PTGS2KDM4EMAOAKMT2A
Cyazofamid SCHEMBL23804496 0.84 PTGS2 (0.37) PTGS1PTGS2KDM4EMAOAKMT2A
SCHEMBL933896 0.84 ADORA1 (0.42) KDM4EALDH1A1HPGDKMT2AMEN1
SCHEMBL1074601 0.83 TSHR (0.34) PTGS2HPGDKMT2ATSHRSMN1; SMN2
SCHEMBL1073894 0.83 PTGS2 (0.46) PTGS1PTGS2KDM4EMAPTLMNA
SCHEMBL9519745 0.76 SMN1; SMN2 (0.33) KDM4ESMN1; SMN2GAA
SCHEMBL7095742 0.75 PTGS2 (0.37) PTGS1PTGS2ALDH1A1MAOAKMT2A
SCHEMBL9520829 0.73 PTGS2 (0.39) PTGS1PTGS2KDM4EALDH1A1HPGD
SCHEMBL932277 0.72 PTGS2 (0.39) PTGS1PTGS2KDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090163567-A1 GERMICIDE COMPOSITION FOR AGRICULTURAL AND GARDENING APPLICATIONS AND METHOD FOR CONTROLLING PLANT DISEASE ISHIHARA SANGYO KAISHA, LTD (JP) 2009-06-25 US claimed
EP-1952689-A1 GERMICIDE COMPOSITION FOR AGRICULTURAL AND GARDENING APPLICATIONS AND METHOD FOR CONTROLLING PLANT DISEASE ISHIHARA SANGYO KAISHA, LTD. (JP) 2008-08-06 EP claimed
US-6713500-B2 IMIDAZOLE DERIVATIVES; FOR CONTROLLING COCCIDIOSIS ISHIHARA SANGYO KAISHA LTD. (JP) 2004-03-30 US claimed
US-8741859-B2 Fungicide composition for agriculture and horticulture and method for preventing plant diseases ISHIHARA SANGYO KAISHA, LTD (JP) 2014-06-03 US disclosed
US-8580288-B2 Agricultural or horticultural fungicide composition and its use for controlling plant pathogens ISHIHARA SANGYO KAISHA, LTD (JP) 2013-11-12 US disclosed
EP-2617287-A1 Germicide composition for agricultural and gardening applications and method for controlling plant disease ISHIHARA SANGYO KAISHA, LTD. (JP) 2013-07-24 EP disclosed
US-20120108644-A1 AGRICULTURAL OR HORTICULTURAL FUNGICIDE COMPOSITION AND ITS USE FOR CONTROLLING PLANT PATHOGENS ISHIHARA SANGYO KAISHA, LTD. (JP) 2012-05-03 US disclosed
US-20110028419-A1 FUNGICIDE COMPOSITION FOR AGRICULTURE AND HORTICULTURE AND METHOD FOR PREVENTING PLANT DISEASES ISHIHARA SANGYO KAISHA, LTD (JP) 2011-02-03 US disclosed
EP-1769679-B1 BACTERICIDAL COMPOSITION FOR AGRICULTURAL OR HORTICULTURAL USE AND METHOD OF CONTROLLING PLANT DISEASE ISHIHARA SANGYO KAISHA (JP) 2011-01-19 EP disclosed
US-7851497-B2 Bactericidal composition for agricultural or horticultural use and method of controlling plant disease ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-12-14 US disclosed
US-20090163567-A1 GERMICIDE COMPOSITION FOR AGRICULTURAL AND GARDENING APPLICATIONS AND METHOD FOR CONTROLLING PLANT DISEASE ISHIHARA SANGYO KAISHA, LTD (JP) 2009-06-25 US disclosed
EP-1419693-A1 COMPOSITION FOR CONTROLLING PLANT PATHOGENIC BACTERIUM AND METHOD OF CONTROLLING PLANT PATHOGENIC BACTERIUM ISHIHARA SANGYO KAISHA, LTD. (JP) 2004-05-19 EP disclosed
EP-1417887-A1 Pesticidal composition and method for controlling pests ISHIHARA SANGYO KAISHA, LTD. (JP) 2004-05-12 EP disclosed
US-6713500-B2 IMIDAZOLE DERIVATIVES; FOR CONTROLLING COCCIDIOSIS ISHIHARA SANGYO KAISHA LTD. (JP) 2004-03-30 US disclosed
EP-1316254-A1 Pesticidal composition and method for controlling pests ISHIHARA SANGYO KAISHA, LTD. (JP) 2003-06-04 EP disclosed
US-20030100586-A1 Agent for controlling animal diseases caused by parasites ISHIHARA SANGYO KAISHA LTD. (JP) 2003-05-29 US disclosed
EP-1194039-B1 PESTICIDAL COMPOSITION AND METHOD FOR CONTROLLING PESTS ISHIHARA SANGYO KAISHA (JP) 2003-05-21 EP disclosed
EP-0979034-B1 COMPOSITION FOR CONTROLLING HARMFUL BIO-ORGANISMS AND METHOD FOR CONTROLLING HARMFUL BIO-ORGANISMS USING THE SAME ISHIHARA SANGYO KAISHA (JP) 2003-02-26 EP disclosed
EP-1211245-A1 AGENTS FOR CONTROLLING ANIMAL DISEASES CAUSED BY PARASITES ISHIHARA SANGYO KAISHA, LTD. (JP) 2002-06-05 EP disclosed
US-6375965-B1 Composition for controlling harmful bio-organisms and method for controlling harmful bio-organisms using the same ISHIHARA SANGYO KAISHA, LTD. (JP) 2002-04-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120108644-A1 AGRICULTURAL OR HORTICULTURAL FUNGICIDE COMPOSITION AND ITS USE FOR CONTROLLING PLANT PATHOGENS CYP51A1, DHFR, PFAS PTGS1 3537/4885PTGS2 3969/4885KDM4E 649/4885
US-20030100586-A1 Agent for controlling animal diseases caused by parasites CLIC1, CLIC4, H1-4 PTGS1 1116/4885PTGS2 1898/4885KDM4E 382/4885
US-20090163567-A1 GERMICIDE COMPOSITION FOR AGRICULTURAL AND GARDENING APPLICATIONS AND METHOD FOR CONTROLLING PLANT DISEASE AGL, GMDS, MGAM PTGS1 1231/4885PTGS2 2421/4885KDM4E 2395/4885
US-20110028419-A1 FUNGICIDE COMPOSITION FOR AGRICULTURE AND HORTICULTURE AND METHOD FOR PREVENTING PLANT DISEASES BROX, PRDX6, GLRX3 PTGS1 3139/4885PTGS2 3960/4885KDM4E 2345/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.