Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9322428 | 0.82 | LOXL2 (0.42) | IDO1KCNJ1KCNH2CA12CA1 | |
| SCHEMBL490893 | 0.80 | KCNJ1 (0.56) | IDO1KCNJ1KCNH2TAAR1MAPT | |
| SCHEMBL11743064 | 0.79 | ALDH1A1 (0.46) | KMT2AMEN1MAPTHTTALDH1A1 | |
| SCHEMBL3030865 | 0.77 | TAAR1 (0.51) | IDO1FBP1CMA1AGXTTAAR1 | |
| SCHEMBL7051536 | 0.77 | KCNJ1 (0.54) | KCNJ1KCNH2TAAR1MAPTNPC1 | |
| SCHEMBL17759030 | 0.77 | NPC1 (0.51) | KCNH2CA12CA1CA2CA7 | |
| SCHEMBL11236036 | 0.77 | LMNA (0.50) | KCNH2CA12CA1CA2CA7 | |
| SCHEMBL1036369 | 0.76 | ACHE (0.50) | IDO1FBP1AGXTTAAR1KMT2A | |
| SCHEMBL9610841 | 0.76 | CA2 (0.45) | IDO1CA2TAAR1KMT2AMEN1 | |
| SCHEMBL8329926 | 0.75 | SMN1; SMN2 (0.50) | FBP1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |
| EP-0359519-B1 | A process for producing carbamic acid esters | BABCOCK HITACHI KK (JP) | 1994-02-02 | — | — | EP | disclosed |
| EP-0296686-B1 | A PROCESS FOR THE PREPARATION OF CARBAMATES | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1992-04-01 | — | — | EP | disclosed |
| US-5101062-A | Reacting an amine, oxygen, a nitro compound, carbon monoxide, and alcohol in the presence of a transition metal catalyst, non-metal halide and water | BABCOCK-HITACHI KABUSHIKI KAISHA (JP) | 1992-03-31 | — | — | US | disclosed |
| EP-0359519-A1 | A process for producing carbamic acid esters | BABCOCK-HITACHI KABUSHIKI KAISHA (JP) | 1990-03-21 | — | — | EP | disclosed |
| EP-0296686-A1 | A process for the preparation of carbamates | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-12-28 | — | — | EP | disclosed |
| EP-0086281-B2 | PREPARATION OF CARBAMATES USING A PALLADIUM-CONTAINING CATALYST | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1988-10-19 | — | — | EP | disclosed |
| EP-0086281-B1 | PREPARATION OF CARBAMATES USING A PALLADIUM-CONTAINING CATALYST | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1985-05-15 | — | — | EP | disclosed |
| US-4474978-A | Preparation of carbamates | SHELL OIL COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0086281-A1 | Preparation of carbamates using a palladium-containing catalyst | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1983-08-24 | — | — | EP | disclosed |
| US-4341898-A | DEHYDROGENATION-ISOMERIZATION REACTION IN PRESENCE OF LEWIS ACID | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1982-07-27 | — | — | US | disclosed |
| US-4079076-A | TREATING NITRO COMPOUNDS WITH PHOSPHORUS TRICHLORIDE IN THE PRESENCE OF PYRIDINE | HOFFMANN-LA ROCHE, INC. (US) | 1978-03-14 | — | — | US | disclosed |
| US-4070391-A | Process for producing isocyanate from nitro compounds and carbon monoxide using rhodium oxide catalysts | ETHYL CORPORATION (US) | 1978-01-24 | — | — | US | disclosed |
| US-4052437-A | PROCESS FOR PRODUCING URETHANE FROM NITRO COMPOUNDS, HYDROXYL COMPOUNDS AND CARBON MONOXIDE USING RHODIUM OXIDE CATALYSTS | ETHYL CORPORATION (US) | 1977-10-04 | — | — | US | disclosed |
| US-3935219-A | Antimicrobial dihalonitromethylisoxazoles | PURDUE RESEARCH LABORATORY (US) | 1976-01-27 | — | — | US | disclosed |