Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9324726 | 0.94 | LMNA (0.60) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL2808656 | 0.93 | LMNA (0.59) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL9325186 | 0.93 | PLA2G2A (0.54) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL9324877 | 0.93 | PLA2G2A (0.54) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL9323897 | 0.93 | PLA2G2A (0.54) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL391547 | 0.92 | MEN1 (0.71) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL2650902 | 0.89 | LMNA (0.60) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL183994 | 0.89 | LMNA (0.70) | LMNAHPGDMEN1KMT2ARAB9A | |
| SCHEMBL9167382 | 0.88 | PLA2G2A (0.58) | LMNAHPGDMEN1KMT2ANPC1 | |
| SCHEMBL31007012 | 0.88 | PLA2G2A (0.58) | LMNAHPGDMEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |