Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9321535 | 0.95 | MAOB (0.37) | MAOBNR1H3CYP51A1MAOAKDM4E | |
| SCHEMBL9764371 | 0.90 | ADRB2 (0.41) | NR1H3KDM4EADRB1BCHE | |
| SCHEMBL9764456 | 0.90 | ADRB2 (0.41) | MAOBNR1H3CYP51A1KDM4EADRB1 | |
| SCHEMBL9764429 | 0.90 | ADRB2 (0.41) | MAOBNR1H3CYP51A1KDM4EADRB1 | |
| SCHEMBL9764301 | 0.87 | NR1H3 (0.45) | MAOBNR1H3MAOABCHE | |
| SCHEMBL9764694 | 0.87 | NR1H3 (0.45) | MAOBNR1H3MAOABCHE | |
| SCHEMBL9764389 | 0.87 | ADRB2 (0.39) | NR1H3CYP51A1KDM4EADRB1BCHE | |
| SCHEMBL10390476 | 0.86 | BCHE (0.46) | MAOBNR1H3MAOABCHEACHE | |
| SCHEMBL9764358 | 0.85 | ADRB2 (0.35) | MAOBNR1H3CYP51A1MAOAKDM4E | |
| SCHEMBL10390440 | 0.85 | NR1H3 (0.44) | MAOBNR1H3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401966-B1 | Phenethanolamine derivatives, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LTD (GB) | 1994-01-19 | — | — | EP | disclosed |
| US-5066678-A | PHENETHANDAMINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | GLAXO GROUP LIMITED (GB) | 1991-11-19 | — | — | US | disclosed |