Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764694 | 0.96 | NR1H3 (0.45) | NR1H3L3MBTL1TDP1MAOAMAOB | |
| SCHEMBL9764371 | 0.91 | ADRB2 (0.41) | NR1H3ADRB2BCHETSHRKCNH2 | |
| SCHEMBL9764429 | 0.89 | ADRB2 (0.41) | NR1H3MAOBADRB2BCHETSHR | |
| SCHEMBL9764456 | 0.89 | ADRB2 (0.41) | NR1H3MAOBADRB2BCHETSHR | |
| SCHEMBL10346955 | 0.89 | TDP1 (0.52) | NR1H3L3MBTL1TDP1MAOAMAOB | |
| SCHEMBL10389958 | 0.88 | ADRB2 (0.41) | NR1H3TDP1ADRB2BCHETSHR | |
| SCHEMBL9764389 | 0.88 | ADRB2 (0.39) | NR1H3ADRB2BCHEKCNH2 | |
| SCHEMBL10417482 | 0.88 | SLC2A1 (0.39) | NR1H3ADRB2BCHETSHRKCNH2 | |
| SCHEMBL9324009 | 0.87 | MAOB (0.39) | NR1H3MAOAMAOBBCHE | |
| SCHEMBL9321535 | 0.86 | MAOB (0.37) | NR1H3MAOAMAOBADRB2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |