Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 9/20 | 0.35 |
| ▸ | MAOA | P21397 | 4/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764429 | 0.87 | ADRB2 (0.41) | ADRB2MAOBNR1H3KDM4EPSEN1 | |
| SCHEMBL9764456 | 0.87 | ADRB2 (0.41) | ADRB2MAOBNR1H3KDM4EPSEN1 | |
| SCHEMBL9764371 | 0.87 | ADRB2 (0.41) | ADRB2NR1H3KDM4EPSEN1PSEN2 | |
| SCHEMBL9321535 | 0.86 | MAOB (0.37) | ADRB2MAOBMAOANR1H3KDM4E | |
| SCHEMBL9324009 | 0.85 | MAOB (0.39) | MAOBMAOANR1H3KDM4ECYP51A1 | |
| SCHEMBL10465949 | 0.83 | ADRB2 (0.33) | ADRB2NR1H3CYP51A1SLC2A1 | |
| SCHEMBL9764329 | 0.82 | ADRB2 (0.39) | ADRB2NR1H3CYP51A1ADRB1SLC6A2 | |
| SCHEMBL9764389 | 0.82 | ADRB2 (0.39) | ADRB2NR1H3KDM4ECYP51A1ADRB1 | |
| SCHEMBL10417482 | 0.82 | SLC2A1 (0.39) | ADRB2NR1H3KDM4ECYP51A1ADRB1 | |
| SCHEMBL9764279 | 0.82 | NR1H3 (0.35) | MAOBNR1H3KDM4ESLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| US-4937251-A | TREATING ASTHMA AND BRONCHITIS; ADRENERGIC STIMULANTS | GLAXO GROUP LIMITED (GB) | 1990-06-26 | — | — | US | disclosed |
| US-4921867-A | Pyridine compounds useful for therapy or prophylaxis of a disease associated with airway obstruction | GLAXO GROUP LIMITED (GB) | 1990-05-01 | — | — | US | disclosed |
| EP-0278728-A2 | 1-(4-Amino-3,5-dichlorophenyl)-2-(substituted amino)ethanol derivatives and their use in the treatment of respiratory disease | GLAXO GROUP LIMITED (GB) | 1988-08-17 | — | — | EP | disclosed |