Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764456 | 0.96 | ADRB2 (0.41) | ADRB2KCNH2KDM4EADRB1HTR1A | |
| SCHEMBL9764429 | 0.96 | ADRB2 (0.41) | ADRB2KCNH2KDM4EADRB1HTR1A | |
| SCHEMBL10389958 | 0.93 | ADRB2 (0.41) | ADRB2KDM4EADRB1HTR1ASLC6A2 | |
| SCHEMBL10417482 | 0.93 | SLC2A1 (0.39) | ADRB2KCNH2KDM4EADRB1HTR1A | |
| SCHEMBL9321535 | 0.91 | MAOB (0.37) | ADRB2KDM4EADRB1HTR1ASLC6A2 | |
| SCHEMBL9764301 | 0.91 | NR1H3 (0.45) | ADRB2KCNH2TSHRBCHENR1H3 | |
| SCHEMBL9764329 | 0.91 | ADRB2 (0.39) | ADRB2ADRB1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9764389 | 0.91 | ADRB2 (0.39) | ADRB2KCNH2KDM4EADRB1MAPK1 | |
| SCHEMBL9324009 | 0.90 | MAOB (0.39) | KDM4EADRB1BCHENR1H3 | |
| SCHEMBL9764460 | 0.90 | LTB4R (0.38) | ADRB2KDM4EMEN1KMT2ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |