Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9764301 | 0.96 | NR1H3 (0.45) | NR1H3L3MBTL1TDP1MAOBMAOA | |
| SCHEMBL9764429 | 0.93 | ADRB2 (0.41) | NR1H3MAOBADRB2TSHRBCHE | |
| SCHEMBL9764456 | 0.93 | ADRB2 (0.41) | NR1H3MAOBADRB2TSHRBCHE | |
| SCHEMBL9764389 | 0.91 | ADRB2 (0.39) | NR1H3ADRB2BCHEKCNH2 | |
| SCHEMBL9764329 | 0.89 | ADRB2 (0.39) | NR1H3ADRB2BCHE | |
| SCHEMBL9764371 | 0.89 | ADRB2 (0.41) | NR1H3ADRB2TSHRBCHEKCNH2 | |
| SCHEMBL9324009 | 0.87 | MAOB (0.39) | NR1H3MAOBMAOABCHE | |
| SCHEMBL9321535 | 0.86 | MAOB (0.37) | NR1H3MAOBMAOAADRB2POLB | |
| SCHEMBL9764542 | 0.86 | ADRB2 (0.41) | NR1H3MAOBADRB2ALDH1A1KCNH2 | |
| SCHEMBL9764242 | 0.85 | MC4R (0.39) | ADRB2NPC1ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006556-A | Dichloroaniline derivatives for the therapy or prophylaxysis of a disease associated with reversible airway obstruction | GLAXO GROUP LIMITED (GB) | 1991-04-09 | — | — | US | disclosed |
| US-4943591-A | TREATMENT OF ASTHMA AND BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-07-24 | — | — | US | disclosed |
| EP-0181709-A1 | Dichloroaniline Derivatives | GLAXO GROUP LIMITED (GB) | 1986-05-21 | — | — | EP | disclosed |