Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325012 | 0.87 | RXRA (0.56) | KDM4EL3MBTL1TDP1HTTLMNA | |
| SCHEMBL9324868 | 0.84 | MAPT (0.61) | L3MBTL1TDP1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9325774 | 0.82 | MAPT (0.55) | KDM4EGAAALDH1A1KMT2AMAPT | |
| SCHEMBL7826725 | 0.79 | MAPT (0.54) | KDM4EL3MBTL1TDP1LMNAGAA | |
| SCHEMBL1543712 | 0.77 | MAPT (0.55) | KDM4EL3MBTL1TDP1LMNAGAA | |
| SCHEMBL9325175 | 0.77 | KMT2A (0.55) | LMNAGAAALDH1A1MEN1KMT2A | |
| SCHEMBL762838 | 0.76 | MAPT (0.55) | MAPTRAB9A | |
| SCHEMBL9323928 | 0.76 | LMNA (0.60) | KDM4EHTTLMNASMN1; SMN2MEN1 | |
| SCHEMBL4601631 | 0.76 | L3MBTL1 (0.53) | KDM4EL3MBTL1TDP1LMNAMAPK1 | |
| SCHEMBL2039160 | 0.76 | KDM4E (0.58) | KDM4EL3MBTL1TDP1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374772-A | Skin disorders, antiinflammatory agents, cardiovascular disorders | HOFFMANN-LAROCHE INC. (US) | 1994-12-20 | — | — | US | disclosed |
| EP-0601385-A1 | Disubstituted benzoic acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-06-15 | — | — | EP | disclosed |