SCHEMBL9325745

SCHEMBL9325745

O=C(Cl)c1ccccc1Oc1ccc(-c2ccccc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 1/20 0.54
CASP1 P29466 1/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
MAPT P10636 3/20 0.46
SMN1; SMN2 Q16637 1/20 0.45
ALDH1A1 P00352 3/20 0.43
L3MBTL1 Q9Y468 3/20 0.43
GAA P10253 2/20 0.43
HTT P42858 2/20 0.43
MAPK8 P45983 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
HPGD P15428 1/20 0.43
ATM Q13315 1/20 0.43
DHODH Q02127 1/20 0.43
RAB9A P51151 1/20 0.43
LMNA P02545 2/20 0.42
NPSR1 Q6W5P4 1/20 0.42
TP53 P04637 1/20 0.42
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9243804 0.89 CTNNB1 (0.62) CTNNB1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL645199 0.89 CTNNB1 (0.67) CTNNB1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL9245660 0.86 CTNNB1 (0.58) CTNNB1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL9244302 0.86 CTNNB1 (0.62) CTNNB1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL9673278 0.83 TTR (0.42) CASP1MAPTSMN1; SMN2L3MBTL1GAA
SCHEMBL11423242 0.83 CTNNB1 (0.54) CTNNB1CASP1MEN1KMT2AMAPT
SCHEMBL10586309 0.81 CDC25B (0.54) CTNNB1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL3357655 0.81 ALDH1A1 (0.52) CTNNB1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL11421571 0.80 SLC6A3 (0.55) CTNNB1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL10783494 0.79 BCAT2 (0.46) CTNNB1MEN1KMT2ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0314384-B1 Preparation of poly(arylene ether ketones) RAYCHEM CORP (US) 1994-02-02 EP disclosed
EP-0430994-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES). RAYCHEM CORP (US) 1991-06-12 EP disclosed
WO-1991002014-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES) RAYCHEM CORPORATION (US) 1991-02-21 WO disclosed
US-4912181-A Preparation of poly(arylene ether ketones) by sequential oligomerization and polyerization in distinct reaction zones RAYCHEM CORPORATION (US) 1990-03-27 US disclosed
WO-1990001509-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES) RAYCHEM CORPORATION (US) 1990-02-22 WO disclosed
WO-1990001510-A1 STABILIZATION OF POLY(ARYLENE ETHER KETONES) RAYCHEM CORPORATION (US) 1990-02-22 WO disclosed
US-4874840-A DIGESTING IN WATER TO DESOLVENTIZE FOLLOWED BY HEAT TREATMENT RAYCHEM CORPORATION (US) 1989-10-17 US disclosed
US-4874839-A HEAT TREATMENT PRIOR TO MELT PROCESSING; DECOLORING; PURIFICATION RAYCHEM CORPORATION (US) 1989-10-17 US disclosed
US-4843131-A Preparation of poly(arylene ether ketones) by sequential oligomerization and polymerization in distinct reaction zones RAYCHEM CORPORATION (US) 1989-06-27 US disclosed
EP-0314384-A2 Preparation of poly(arylene ether ketones) RAYCHEM CORPORATION (a Delaware corporation) (US) 1989-05-03 EP disclosed
US-4716211-A 1,2-DICHLOROETHANE SOLVENT AMOCO CORPORATION (US) 1987-12-29 US disclosed
US-4710562-A Stabilizing polyaryletherketones AMOCO CORPORATION (US) 1987-12-01 US disclosed
US-4611033-A Process for stabilizing a poly(aryl ether ketone) UNION CARBIDE CORPORATION (US) 1986-09-09 US disclosed
US-4229564-A SUITABLE FOR MELT PROCESSING AND EXTRUSION COATINGS RAYCHEM CORPORATION (US) 1980-10-21 US disclosed
US-4111908-A POLYKETONES AND METHODS THEREFOR RAYCHEM CORPORATION (US) 1978-09-05 US disclosed
US-3965146-A POLYMER INTERMEDIATE RAYCHEM CORPORATION (US) 1976-06-22 US disclosed