Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | FOS | P01100 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18269146 | 0.87 | GABRA1 (0.52) | TTRFOSJUNNR3C1HSD17B1 | |
| SCHEMBL11156645 | 0.86 | ALOX15 (0.47) | TTRFOSJUNNR3C1HSD17B1 | |
| SCHEMBL3901814 | 0.86 | TTR (0.47) | TTRFOSJUNNR3C1HSD17B1 | |
| SCHEMBL18752221 | 0.84 | TAAR1 (0.50) | TTRFOSJUNNR3C1HSD17B1 | |
| SCHEMBL448168 | 0.83 | FOS (0.51) | TTRFOSJUNNR3C1HSD17B1 | |
| SCHEMBL11838721 | 0.82 | CA2 (0.61) | TTR | |
| SCHEMBL31435284 | 0.80 | PTGS2 (0.48) | TTRLDHA | |
| SCHEMBL806723 | 0.80 | CA2 (0.63) | TTRFOSJUNNR3C1HSD17B1 | |
| SCHEMBL8595058 | 0.79 | FOS (0.44) | TTRFOSJUNNR3C1HSD17B1 | |
| SCHEMBL1829321 | 0.79 | NPC1 (0.47) | TTRLDHAMMP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |