SCHEMBL9326290

SCHEMBL9326290

CCCCCCCCCCCCC(OC(=O)C(Cl)(Cl)Cl)c1coc([Si](C)(C)C)c1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.33
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9325034 0.85 GLS2 (0.35) ALDH1A1
SCHEMBL9670950 0.85 GLS2 (0.35) ALDH1A1
SCHEMBL7295059 0.85 GLS2 (0.35) ALDH1A1
SCHEMBL9671037 0.85 GLS2 (0.35) ALDH1A1
SCHEMBL9325309 0.83 LMNA (0.42) MAPTALDH1A1
Benzene SCHEMBL9326381 0.83 ALDH1A1 (0.36) ALDH1A1
SCHEMBL9671711 0.82 EPHX1 (0.35) ALDH1A1
SCHEMBL9746369 0.82 ALDH2 (0.33) MAPTALDH1A1
SCHEMBL9745263 0.81 LMNA (0.37) MAPTALDH1A1
SCHEMBL9671361 0.80 SIGMAR1 (0.35) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5322953-A Antiinflammatory agents; intermediates for 2-furanone compounds ALLERGAN, INC. (US) 1994-06-21 US disclosed
US-5298633-A Silane intermediates ALLERGAN, INC. (US) 1994-03-29 US disclosed
US-5171863-A 2-trialkylsily-4-substituted furan derivatives ALLERGAN, INC. (US) 1992-12-15 US disclosed
EP-0295056-B1 ANTI-INFLAMMATORY FURANONES ALLERGAN, INC (US) 1992-08-05 EP disclosed
US-5134128-A Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis ALLERGAN, INC. (US) 1992-07-28 US disclosed
US-5082954-A Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents ALLERGAN, INC. (US) 1992-01-21 US disclosed
EP-0295056-A1 Anti-inflammatory furanones ALLERGAN, INC (US) 1988-12-14 EP disclosed