Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS2 | Q9UI32 | 3/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PDCD4 | Q53EL6 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9671037 | 1.00 | GLS2 (0.35) | GLS2SIGMAR1PDCD4ALOX5FAAH | |
| SCHEMBL7295059 | 1.00 | GLS2 (0.35) | GLS2SIGMAR1PDCD4ALOX5FAAH | |
| SCHEMBL9325034 | 1.00 | GLS2 (0.35) | GLS2SIGMAR1PDCD4ALOX5FAAH | |
| Benzene SCHEMBL9326381 | 0.97 | ALDH1A1 (0.36) | GLS2SIGMAR1PDCD4ALOX5ALDH1A1 | |
| SCHEMBL9671361 | 0.95 | SIGMAR1 (0.35) | SIGMAR1ALDH1A1PRKCA | |
| SCHEMBL9803456 | 0.90 | GLS2 (0.34) | GLS2SIGMAR1PDCD4ALOX5FAAH | |
| SCHEMBL9671631 | 0.90 | ALOX5 (0.42) | SIGMAR1ALOX5 | |
| SCHEMBL9670731 | 0.90 | ALOX5 (0.42) | SIGMAR1ALOX5 | |
| SCHEMBL9671482 | 0.89 | SIGMAR1 (0.33) | SIGMAR1ALOX5FAAHALDH1A1 | |
| SCHEMBL9325309 | 0.88 | LMNA (0.42) | ALDH1A1PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295056-B1 | ANTI-INFLAMMATORY FURANONES | ALLERGAN, INC (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5134128-A | Immunosuppressive and antiproliferative activity for psoriasis and calcium homeostasis | ALLERGAN, INC. (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0295056-A1 | Anti-inflammatory furanones | ALLERGAN, INC (US) | 1988-12-14 | — | — | EP | disclosed |