Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CHUK | O15111 | 3/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932971 | 0.80 | MCOLN3 (0.58) | ALDH1A1PKMHTT | |
| SCHEMBL932636 | 0.79 | ALDH1A1 (0.50) | ALDH1A1PKM | |
| SCHEMBL931510 | 0.77 | PKM (0.59) | KDM4EALDH1A1HPGDPKMHTT | |
| SCHEMBL9950422 | 0.76 | PKM (0.64) | MAPTKDM4EALDH1A1PKMHTT | |
| SCHEMBL932795 | 0.76 | LMNA (0.42) | GBA1KDM4EPKMHTT | |
| SCHEMBL933278 | 0.72 | KMT2A (0.54) | MAPTALDH1A1PKMHTT | |
| SCHEMBL932990 | 0.72 | PKM (0.62) | ALDH1A1PKMHTT | |
| SCHEMBL932085 | 0.72 | SMN1; SMN2 (0.55) | MAPTPKMHTT | |
| SCHEMBL8414638 | 0.71 | IKBKB (0.60) | GBA1CHRM5RAB9AMAPTKDM4E | |
| SCHEMBL28013845 | 0.71 | RAB9A (0.67) | GBA1CHRM5RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448581-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | Agios Pharmaceuticals, Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011002816-A1 | THERAPEUTIC COMPOSITIONS AND RELATED METHODS OF USE | AGIOS PHARMACEUTICALS, INC. (US) | 2011-01-06 | — | — | WO | disclosed |