SCHEMBL9328862

SCHEMBL9328862

O=C(O)Cc1cccc2c(=O)cc(-c3c(F)c(F)c(F)c(F)c3F)oc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
NPC1 O15118 2/20 0.51
LMNA P02545 2/20 0.51
NPSR1 Q6W5P4 2/20 0.51
OPRD1 P41143 1/20 0.51
OPRK1 P41145 1/20 0.51
GLA P06280 1/20 0.46
STING1 Q86WV6 1/20 0.46
CYP2D6 P10635 3/20 0.46
CYP1A2 P05177 5/20 0.45
CYP3A4 P08684 2/20 0.45
CYP2C19 P33261 2/20 0.45
STAT6 P42226 1/20 0.45
TP53 P04637 2/20 0.44
MAPT P10636 2/20 0.44
MAPK1 P28482 2/20 0.44
POLB P06746 1/20 0.44
XBP1 P17861 1/20 0.44
HTT P42858 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9327921 0.93 CYP2D6 (0.44) ALDH1A1NPC1LMNANPSR1OPRD1
SCHEMBL9327573 0.90 GLA (0.46) ALDH1A1NPC1LMNANPSR1OPRD1
SCHEMBL9328479 0.88 CYP2D6 (0.44) ALDH1A1NPC1LMNANPSR1OPRD1
SCHEMBL9327602 0.85 CYP2D6 (0.43) ALDH1A1NPC1LMNANPSR1OPRD1
SCHEMBL9328729 0.85 CYP2D6 (0.49) ALDH1A1GLASTING1CYP2D6CYP1A2
SCHEMBL9329003 0.84 CYP1A2 (0.48) ALDH1A1NPC1GLASTING1CYP2D6
SCHEMBL9327900 0.84 CYP1A2 (0.56) ALDH1A1GLASTING1CYP2D6CYP1A2
SCHEMBL9327677 0.84 CYP2D6 (0.53) ALDH1A1GLASTING1CYP2D6CYP1A2
SCHEMBL9328990 0.83 CYP2D6 (0.43) ALDH1A1NPC1GLASTING1CYP2D6
Mitoflaxone SCHEMBL106705 0.83 CYP1A2 (0.62) ALDH1A1NPC1GLASTING1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0454728-B1 FLUORINATED FLAVONE ACETIC ACID UPJOHN CO (US) 1994-03-16 EP claimed
US-5238954-A Antitumor agents THE UPJOHN COMPANY (US) 1993-08-24 US claimed
EP-0454728-A1 FLUORINATED FLAVONE ACETIC ACID. UPJOHN CO (US) 1991-11-06 EP claimed
WO-1990008143-A1 FLUORINATED FLAVONE ACETIC ACID THE UPJOHN COMPANY (US) 1990-07-26 WO claimed
EP-0454728-B1 FLUORINATED FLAVONE ACETIC ACID UPJOHN CO (US) 1994-03-16 EP disclosed
US-5238954-A Antitumor agents THE UPJOHN COMPANY (US) 1993-08-24 US disclosed
EP-0454728-A1 FLUORINATED FLAVONE ACETIC ACID. UPJOHN CO (US) 1991-11-06 EP disclosed
WO-1990008143-A1 FLUORINATED FLAVONE ACETIC ACID THE UPJOHN COMPANY (US) 1990-07-26 WO disclosed