Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL933449 | 0.82 | ALDH1A1 (0.33) | HPGDALDH1A1LMNAMAPK1KDM4E | |
| SCHEMBL27854294 | 0.80 | HPGD (0.40) | HPGDALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL27854296 | 0.72 | ALDH1A1 (0.38) | HPGDALDH1A1LMNAMAPK1 | |
| SCHEMBL27854282 | 0.68 | KDM4E (0.34) | HPGDALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL27854286 | 0.67 | ALDH1A1 (0.32) | HPGDALDH1A1LMNAMAPK1KDM4E | |
| SCHEMBL28801600 | 0.66 | DGAT1 (0.34) | ALDH1A1LMNASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL18683365 | 0.65 | LMNA (0.35) | HPGDALDH1A1LMNAKDM4E | |
| SCHEMBL16952185 | 0.65 | LMNA (0.33) | LMNA | |
| SCHEMBL932912 | 0.64 | ALDH1A1 (0.40) | HPGDALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL966670 | 0.64 | ALDH1A1 (0.40) | HPGDALDH1A1LMNATSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005738-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | WO | disclosed |