Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL932913 | 0.82 | HPGD (0.42) | ALDH1A1HPGDMAPK1LMNAKDM4E | |
| SCHEMBL27854286 | 0.78 | ALDH1A1 (0.32) | ALDH1A1HPGDMAPK1LMNAKDM4E | |
| SCHEMBL16465962 | 0.74 | MAOB (0.37) | ALDH1A1MEN1HTTKMT2A | |
| SCHEMBL17604471 | 0.71 | PYCR1 (0.33) | LMNAMEN1KMT2A | |
| SCHEMBL27854282 | 0.71 | KDM4E (0.34) | ALDH1A1HPGDMAPK1LMNAKDM4E | |
| SCHEMBL15923004 | 0.70 | DGAT1 (0.35) | ALDH1A1LMNAKMT2A | |
| SCHEMBL17604466 | 0.70 | DGAT1 (0.35) | ALDH1A1LMNAKMT2A | |
| SCHEMBL1711933 | 0.69 | SLC6A2 (0.35) | ALDH1A1MEN1KMT2A | |
| SCHEMBL28801600 | 0.69 | DGAT1 (0.34) | ALDH1A1LMNAKDM4EHSD17B10MEN1 | |
| SCHEMBL27697292 | 0.68 | APLNR (0.38) | ALDH1A1LMNAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3010925-A1 | BACE INHIBITORS | Eli Lilly & Company (US) | 2016-04-27 | — | — | EP | disclosed |
| WO-2014204730-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2014-12-24 | — | — | WO | disclosed |
| EP-2451793-A1 | BACE INHIBITORS | Eli Lilly and Company (US) | 2012-05-16 | — | — | EP | disclosed |
| WO-2011005738-A1 | BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2011-01-13 | — | — | WO | disclosed |