Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.61 |
| ▸ | TYR | P14679 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.61 |
| ▸ | MIF | P14174 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.42 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14950660 | 0.79 | KIF11 (0.44) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| SCHEMBL2160202 | 0.78 | ALDH1A1 (0.70) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| E319 SCHEMBL27469266 | 0.76 | ALDH1A1 (1.00) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| SCHEMBL30629387 | 0.76 | ALDH1A1 (0.67) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| SCHEMBL1972679 | 0.76 | ALDH1A1 (0.35) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| E319 SCHEMBL26745 | 0.76 | ALDH1A1 (1.00) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| E319 SCHEMBL29350903 | 0.76 | ALDH1A1 (1.00) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| SCHEMBL7858673 | 0.76 | ALDH1A1 (0.67) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| SCHEMBL10664383 | 0.76 | ALDH1A1 (0.59) | ALDH1A1ALOX15TYRLMNACYP2C9 | |
| SCHEMBL10176702 | 0.76 | ALDH1A1 (0.59) | ALDH1A1ALOX15TYRLMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0479631-B1 | Spiro[4,5]decane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1994-11-02 | — | — | EP | disclosed |
| EP-0293900-B1 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | SEARLE & CO (US) | 1994-03-16 | — | — | EP | disclosed |
| EP-0293899-B1 | PHENOLIC THIOALKYLAMIDES AS INHIBITORS OF 5-LIPOXYGENASE | G.D. Searle & Co. (US) | 1993-10-13 | — | — | EP | disclosed |
| EP-0293895-B1 | PHENOLIC THIOETHERS AS INHIBITORS OF 5-LIPOXYGENASE | G.D. Searle & Co. (US) | 1993-08-11 | — | — | EP | disclosed |
| EP-0479631-A1 | Spiro[4,5]decane derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-04-08 | — | — | EP | disclosed |
| EP-0206979-B1 | BIS(SUBSTITUTED THIOALKYL)HYDROXYL AMINES AND STABILIZED POLYOLEFIN COMPOSITIONS | CIBA-GEIGY AG (CH) | 1989-12-06 | — | — | EP | disclosed |
| EP-0293899-A1 | Phenolic thioalkylamides as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | disclosed |
| EP-0293900-A2 | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | disclosed |
| EP-0293895-A1 | Phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1988-12-07 | — | — | EP | disclosed |
| EP-0235575-A1 | Novel phenolic thioethers as inhibitors of 5-lipoxygenase | G.D. Searle & Co. (US) | 1987-09-09 | — | — | EP | disclosed |
| EP-0093922-B1 | BENZOXAZIN-2-ONES, THEIR PREPARATION AND THERAPEUTIC AGENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1986-12-30 | — | — | EP | disclosed |