Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330429 | 0.81 | L3MBTL1 (0.56) | TDP1L3MBTL1ACHEHPGDALDH1A1 | |
| SCHEMBL7326127 | 0.80 | L3MBTL1 (0.54) | TDP1L3MBTL1ACHEHPGDALDH1A1 | |
| SCHEMBL10725421 | 0.79 | L3MBTL1 (0.59) | TDP1L3MBTL1ACHEHPGDALDH1A1 | |
| SCHEMBL4925328 | 0.78 | ALDH1A1 (0.52) | TDP1L3MBTL1ALDH1A1LMNATSHR | |
| SCHEMBL6789754 | 0.77 | ALDH1A1 (0.57) | TDP1L3MBTL1ACHEHPGDALDH1A1 | |
| SCHEMBL5146080 | 0.75 | ITGB3 (0.40) | TDP1L3MBTL1ALDH1A1LMNATSHR | |
| SCHEMBL5094773 | 0.74 | L3MBTL1 (0.55) | TDP1L3MBTL1ACHEHPGDALDH1A1 | |
| SCHEMBL6578347 | 0.74 | TDP1 (0.51) | TDP1L3MBTL1ACHEALDH1A1LMNA | |
| SCHEMBL5574643 | 0.73 | HDAC8 (0.59) | TDP1L3MBTL1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL5574642 | 0.73 | HDAC8 (0.59) | TDP1L3MBTL1HPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304549-A | Control or prevention of degenerative joint diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-04-19 | — | — | US | disclosed |
| EP-0497192-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1992-08-05 | — | — | EP | disclosed |