Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154781 | 0.98 | LMNA (0.45) | LMNAFNTAFNTBCYP1A2PTGS1 | |
| Hydrochloric Acid SCHEMBL9240522 | 0.89 | LMNA (0.39) | LMNAFNTAFNTBCYP1A2PTGS1 | |
| SCHEMBL8757698 | 0.82 | CYP1A2 (0.37) | LMNAFNTAFNTBCYP1A2PTGS1 | |
| SCHEMBL157503 | 0.82 | CALM1 (0.43) | TDP1TAAR1IDO1 | |
| SCHEMBL9243767 | 0.81 | LMNA (0.36) | LMNAFNTAFNTBCYP1A2PTGS1 | |
| Hydrochloric Acid SCHEMBL3038821 | 0.80 | MMP3 (0.41) | LMNAFNTAFNTBCYP1A2PTGS1 | |
| SCHEMBL155778 | 0.78 | MMP3 (0.43) | LMNAFNTAFNTBCYP1A2PTGS1 | |
| SCHEMBL9357293 | 0.74 | CALM1 (0.36) | TDP1TAAR1IDO1 | |
| SCHEMBL4852324 | 0.72 | MMP3 (0.42) | LMNAFNTAFNTBCYP1A2PTGS1 | |
| SCHEMBL30931353 | 0.72 | LMNA (0.38) | LMNAFNTAFNTBCYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5359017-A | Using an organoiron compound | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1994-10-25 | — | — | US | disclosed |
| EP-0511405-A1 | CATIONICALLY POLYMERIZABLE ORGANIC MATERIAL COMPOSITION AND STABILIZATION OF SAID COMPOSITION | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1992-11-04 | — | — | EP | disclosed |