SCHEMBL9330825

SCHEMBL9330825

CCn1c(C)cc(=O)c(C(=O)O)c1-c1cccc(F)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.44
ALDH1A1 P00352 2/20 0.44
POLB P06746 1/20 0.44
HPGD P15428 1/20 0.44
NR4A1 P22736 1/20 0.40
NR4A2 P43354 1/20 0.40
NR4A3 Q92570 1/20 0.40
MAPT P10636 2/20 0.38
DCLRE1B Q9H816 1/20 0.38
NOTUM Q6P988 1/20 0.38
KDM4C Q9H3R0 1/20 0.38
PTGER1 P34995 1/20 0.38
DHODH Q02127 3/20 0.37
PDE4B Q07343 1/20 0.37
GRIA2 P42262 1/20 0.36
GRIA4 P48058 1/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
KMO O15229 2/20 0.36
MEN1 O00255 1/20 0.36
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9330776 0.87 ALDH1A1 (0.57) KDM4EALDH1A1POLBHPGDMAPT
SCHEMBL9333435 0.86 KDM4E (0.44) KDM4EALDH1A1POLBHPGDMAPT
SCHEMBL9330865 0.85 RAB9A (0.46) KDM4EALDH1A1POLBHPGDMAPT
SCHEMBL10600200 0.83 KDM4C (0.42) NR4A1NR4A2NR4A3DCLRE1BNOTUM
SCHEMBL9333387 0.80 KDM4E (0.46) KDM4EALDH1A1POLBHPGDMAPT
SCHEMBL9330760 0.79 POLB (0.43) KDM4EALDH1A1POLBHPGDMAPT
SCHEMBL9333945 0.78 KDM4E (0.44) KDM4EALDH1A1POLBHPGDNR4A1
SCHEMBL122379 0.78 KMT2A (0.49) KDM4EALDH1A1POLBHPGDMAPT
SCHEMBL9330565 0.78 POLB (0.41) KDM4EALDH1A1POLBHPGDKDM4C
SCHEMBL10463549 0.77 KMT2A (0.48) KDM4EALDH1A1POLBHPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0364183-B1 Chemical hybridisation of dicots ZENECA LTD (GB) 1994-03-30 EP disclosed
US-4964896-A GAMETOCIDES MONSANTO COMPANY (US) 1990-10-23 US disclosed
US-4936904-A Aryl-4-oxonicotinates useful for inducing male sterility in cereal grain plants MONSANTO TECHNOLOGY LLC 1990-06-26 US disclosed
EP-0364183-A2 Chemical hybridisation of dicots ZENECA LIMITED (GB) 1990-04-18 EP disclosed
EP-0127313-B1 THE PRODUCTION OF HAPLOID SEED, OF DOUBLED HAPLOIDS AND OF HOMOZYGOUS PLANT LINES THEREFROM CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1989-07-19 EP disclosed
US-4714492-A HYBRIDIZATION AGENTS ROHM AND HAAS COMPANY (US) 1987-12-22 US disclosed
EP-0127313-A1 The production of haploid seed, of doubled haploids and of homozygous plant lines therefrom CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1984-12-05 EP disclosed
EP-0040082-B1 NOVEL SUBSTITUTED OXONICOTINATES, THEIR USE AS PLANT GROWTH REGULATORS AND PLANT GROWTH REGULATING COMPOSITIONS CONTAINING THEM ROHM AND HAAS COMPANY (US) 1984-04-25 EP disclosed