Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | PTAFR | P25105 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339657 | 0.81 | SLC29A1 (0.39) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9338356 | 0.79 | KDM4E (0.37) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9729169 | 0.77 | ALDH1A1 (0.36) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL7212713 | 0.74 | ACHE (0.45) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9337959 | 0.71 | ALDH1A1 (0.41) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9338007 | 0.70 | ALDH1A1 (0.34) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9337961 | 0.70 | OPRM1 (0.51) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| Dimethylamine SCHEMBL9337974 | 0.70 | ALDH1A1 (0.40) | MAPTCYP3A4KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9337958 | 0.70 | MAPT (0.40) | MAPTCYP3A4ALDH1A1HTTMEN1 | |
| SCHEMBL13946563 | 0.68 | MAOA (0.42) | ALDH1A1HTTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450995-B1 | New propanamines, their pharmacological properties and their therapeutical applications, notably as anti-diarrhoea agents | JOUVEINAL SA (FR) | 1994-06-08 | — | — | EP | disclosed |
| US-5236947-A | Side effect reduction | JOUVEINAL S.A. (FR) | 1993-08-17 | — | — | US | disclosed |
| US-5143938-A | PROPANAMINES, THEIR PHARMACOLOGICAL PROPERTIES AND THEIR APPLICATION FOR THERAPEUTIC IN PARTICULAR ANTIDIARRHEAL, PURPOSES | JOUVEINAL S.A. (FR) | 1992-09-01 | — | — | US | disclosed |