Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.36 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757049 | 0.80 | NR4A2 (0.41) | NR4A2CYSLTR2CYSLTR1CNR2AR | |
| SCHEMBL9335094 | 0.79 | BACE1 (0.36) | UGT2B7CNR2CDK8BRD4BRD2 | |
| SCHEMBL1592247 | 0.79 | CBLB (0.34) | CBLB | |
| SCHEMBL1400950 | 0.79 | CBLB (0.34) | CBLB | |
| SCHEMBL5214449 | 0.78 | — | — | |
| SCHEMBL3228023 | 0.78 | CNR2 (0.43) | NR4A2CNR2AR | |
| SCHEMBL9335423 | 0.77 | PRSS1 (0.38) | NR4A2CYSLTR2CYSLTR1CNR2AR | |
| SCHEMBL4957637 | 0.77 | MAPT (0.44) | CBLBCYSLTR1CNR2CDK8 | |
| SCHEMBL9335553 | 0.76 | UNG (0.41) | CBLBNR4A2CYSLTR2CYSLTR1CNR2 | |
| SCHEMBL9756946 | 0.75 | CYSLTR2 (0.45) | CBLBNR4A2CYSLTR2CYSLTR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |