Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.33 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9757049 | 0.82 | NR4A2 (0.41) | CNR2NR4A2CYSLTR1CYSLTR2MAPT | |
| SCHEMBL3228023 | 0.80 | CNR2 (0.43) | MRGPRX4CNR2NR4A2NPC1MAPT | |
| SCHEMBL9335553 | 0.78 | UNG (0.41) | CNR2NR4A2CYSLTR1NPC1CYSLTR2 | |
| SCHEMBL9339015 | 0.77 | CBLB (0.41) | CNR2NR4A2CYSLTR1CYSLTR2AR | |
| SCHEMBL9339080 | 0.76 | XDH (0.51) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4957637 | 0.76 | MAPT (0.44) | MRGPRX4CNR2CYSLTR1NPC1TP53 | |
| SCHEMBL9383652 | 0.76 | HSD17B10 (0.42) | KCNH2NPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL8521342 | 0.76 | CNR2 (0.44) | CNR2NPC1TP53MAPTRAB9A | |
| SCHEMBL9756946 | 0.74 | CYSLTR2 (0.45) | MRGPRX4CNR2NR4A2CYSLTR1NPC1 | |
| SCHEMBL2050999 | 0.74 | MEN1 (0.39) | CNR2CYSLTR1NPC1CYSLTR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533695-B1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER (US) | 1994-10-05 | — | — | EP | disclosed |
| US-5322847-A | Inhibit platelet activating factor, block leukotriene D4 receptors | PFIZER INC. (US) | 1994-06-21 | — | — | US | disclosed |
| EP-0533695-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY. | PFIZER (US) | 1993-03-31 | — | — | EP | disclosed |
| WO-1991017163-A1 | IMIDAZO (4,5-c) PYRIDINES WITH PAF ANTAGONIST ACTIVITY | PFIZER INC. (US) | 1991-11-14 | — | — | WO | disclosed |