Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3228023 | 0.83 | CNR2 (0.43) | NR4A2CNR2MEN1ALDH1A1KMT2A | |
| SCHEMBL9335423 | 0.82 | PRSS1 (0.38) | NR4A2CNR2MAPTSMN1; SMN2AR | |
| SCHEMBL9335553 | 0.81 | UNG (0.41) | NR4A2CNR2MEN1ALDH1A1KMT2A | |
| SCHEMBL9339015 | 0.80 | CBLB (0.41) | NR4A2CNR2ARCYSLTR2CYSLTR1 | |
| SCHEMBL4957637 | 0.79 | MAPT (0.44) | CNR2TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL9756946 | 0.77 | CYSLTR2 (0.45) | NR4A2CNR2MEN1ALDH1A1KMT2A | |
| SCHEMBL2050999 | 0.75 | MEN1 (0.39) | CNR2TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL18463776 | 0.72 | NR4A2 (0.43) | NR4A2CNR2MEN1ALDH1A1KMT2A | |
| SCHEMBL10403176 | 0.71 | CYSLTR2 (0.60) | NR4A2TSHRMEN1ALDH1A1KMT2A | |
| SCHEMBL10403047 | 0.71 | CYSLTR2 (0.60) | NR4A2TSHRMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |