Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957637 | 0.81 | MAPT (0.44) | CYSLTR1CNR2LMNAMEN1KMT2A | |
| SCHEMBL3228023 | 0.80 | CNR2 (0.43) | CNR2LMNAMEN1KMT2ANPC1 | |
| SCHEMBL9757049 | 0.77 | NR4A2 (0.41) | CYSLTR2CYSLTR1CNR2LMNAMEN1 | |
| SCHEMBL3809767 | 0.76 | CYSLTR1 (0.41) | CYSLTR2CYSLTR1CNR2LMNAMAPT | |
| SCHEMBL9335553 | 0.76 | UNG (0.41) | CYSLTR2CYSLTR1CNR2LMNAMEN1 | |
| SCHEMBL9339015 | 0.75 | CBLB (0.41) | CYSLTR2CYSLTR1CNR2NR4A2CBLB | |
| SCHEMBL9335423 | 0.74 | PRSS1 (0.38) | CYSLTR2CYSLTR1CNR2NPC1RAB9A | |
| SCHEMBL2050999 | 0.74 | MEN1 (0.39) | CYSLTR2CYSLTR1CNR2CYP3A4MEN1 | |
| SCHEMBL718960 | 0.72 | LMNA (0.54) | LMNACYP3A4MEN1KMT2ANPC1 | |
| SCHEMBL9756948 | 0.72 | CYSLTR1 (0.69) | CYSLTR2CYSLTR1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991019475-A2 | QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D¿4? | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1991-12-26 | — | — | WO | disclosed |
| US-5041453-A | Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-08-20 | — | — | US | disclosed |