Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2675687 | 0.80 | DDAH1 (0.56) | NPC1RAB9AKMT2AHSD17B10MAPT | |
| Hydrochloric Acid SCHEMBL28081465 | 0.79 | DDAH1 (0.55) | NPC1RAB9AKMT2AHSD17B10MAPT | |
| SCHEMBL20436746 | 0.76 | KDM4C (0.43) | KDM4CNPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL29991554 | 0.73 | CYP1A2 (0.60) | NPC1RAB9AKMT2AHSD17B10MAPT | |
| SCHEMBL31578022 | 0.73 | CYP1A2 (0.46) | KDM4CNPC1RAB9AKMT2AHSD17B10 | |
| SCHEMBL19312483 | 0.73 | KDM4C (0.42) | KDM4CKMT2A | |
| SCHEMBL20424556 | 0.71 | ALDH1A1 (0.49) | KDM4CKMT2AHSD17B10MAPTKDM4E | |
| SCHEMBL1796547 | 0.71 | PIN1 (0.51) | NPC1RAB9AHPGD | |
| SCHEMBL11271873 | 0.70 | KDM4C (0.39) | KDM4CNPC1RAB9APDE3BPDE3A | |
| SCHEMBL11271918 | 0.70 | MMP2 (0.49) | KDM4CNPC1RAB9AKMT2APDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5281615-A | Hypotensive agents | G. D. SEARLE & CO. (US) | 1994-01-25 | — | — | US | disclosed |
| US-5104891-A | CYCLOHEPTIMIDAZOLONE COMPOUNDS AS ANGIOTENSIN II ANTAGONISTS FOR CONTROL OF HYPERTENSION | G. D. SEARLE & CO. (US) | 1992-04-14 | — | — | US | disclosed |