Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 10/20 | 0.64 |
| ▸ | F2 | P00734 | 8/20 | 0.64 |
| ▸ | PRSS3 | P35030 | 7/20 | 0.64 |
| ▸ | PRSS2 | P07478 | 6/20 | 0.64 |
| ▸ | PLAU | P00749 | 2/20 | 0.61 |
| ▸ | MASP2 | O00187 | 1/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.54 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.52 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.51 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | C1R | P00736 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | PLG | P00747 | 1/20 | 0.51 |
| ▸ | F12 | P00748 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10941768 | 0.98 | PRSS1 (0.62) | PRSS1F2PRSS3PRSS2PLAU | |
| SCHEMBL346698 | 0.89 | PRSS1 (0.71) | PRSS1F2PRSS3PRSS2PKM | |
| SCHEMBL347429 | 0.89 | PRSS1 (0.71) | PRSS1F2PRSS3PRSS2PKM | |
| SCHEMBL107649 | 0.89 | PRSS1 (0.71) | PRSS1F2PRSS3PRSS2PKM | |
| SCHEMBL7744358 | 0.86 | PARP10 (0.74) | PRSS1F2PRSS3PRSS2PLAU | |
| SCHEMBL7342376 | 0.85 | F12 (0.71) | PRSS1F2PRSS3PRSS2PLAU | |
| SCHEMBL10492899 | 0.84 | PARP10 (0.53) | PRSS1F2PRSS3PRSS2PLAU | |
| SCHEMBL10891811 | 0.84 | PRSS1 (0.65) | PRSS1F2PRSS3PRSS2PLAU | |
| Hydrochloric Acid SCHEMBL3402436 | 0.84 | PARP10 (0.72) | PRSS1F2PRSS3PRSS2PKM | |
| SCHEMBL10890871 | 0.84 | PRSS1 (0.72) | PRSS1F2PRSS3PRSS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0196920-B1 | Degraded species of tissue-type plasminogen activator, pharmaceutical composition and method of preparation | BEECHAM GROUP PLC (GB) | 1994-07-06 | — | — | EP | disclosed |
| EP-0283563-B1 | NOVEL DERIVATIVES | BEECHAM GROUP PLC (GB) | 1991-05-29 | — | — | EP | disclosed |
| US-4992274-A | Tissue plasminogen activator A-chain/urokinase B-chain hybrid protein | BEECHAM GROUP P.L.C. (GB) | 1991-02-12 | — | — | US | disclosed |
| US-4970159-A | Human tissue plasminogen activator consisting essentially of t-PA residues 160 to 527 | BEECHAM GROUP P.L.C. (GB) | 1990-11-13 | — | — | US | disclosed |
| US-4908204-A | Reversibly blocked plasmin, t-PA hybrid fibrinolytic enzymes and pharmaceutical compositions and anti-thrombotic use thereof | BEECHAM GROUP P.L.C. (GB) | 1990-03-13 | — | — | US | disclosed |
| US-4880776-A | Plasmin A-chain urokinase B-chain hybrid protein | BEECHAM GROUP P.L.C. (GB) | 1989-11-14 | — | — | US | disclosed |
| EP-0155387-B1 | FIBRONOLYTICALLY ACTIVE HYBRID PROTEIN, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION | BEECHAM GROUP PLC (GB) | 1989-09-06 | — | — | EP | disclosed |
| EP-0155388-B1 | ENZYME-PROTEIN CONJUGATE, PROCESS FOR ITS PREPARATION AND PHARMACEUTICAL USE THEREOF | BEECHAM GROUP PLC (GB) | 1989-03-29 | — | — | EP | disclosed |
| EP-0151593-B1 | ENZYME DERIVATIVES | BEECHAM GROUP PLC (GB) | 1989-02-22 | — | — | EP | disclosed |
| EP-0283563-A2 | Novel derivatives | BEECHAM GROUP PLC (GB) | 1988-09-28 | — | — | EP | disclosed |
| EP-0155388-A2 | Enzyme-protein conjugate, process for its preparation and pharmaceutical use thereof | BEECHAM GROUP PLC (GB) | 1985-09-25 | — | — | EP | disclosed |
| EP-0155387-A2 | Fibronolytically active hybrid protein, process for its preparation and pharmaceutical composition | BEECHAM GROUP PLC (GB) | 1985-09-25 | — | — | EP | disclosed |
| EP-0152736-A2 | Enzyme-protein conjugate, process for its preparation and pharmaceutical composition | BEECHAM GROUP PLC (GB) | 1985-08-28 | — | — | EP | disclosed |
| EP-0151593-A1 | ENZYME DERIVATIVES. | BEECHAM GROUP PLC (GB) | 1985-08-21 | — | — | EP | disclosed |
| US-4507283-A | STREPTOKINASE-HUMAN PLASMINOGEN ACTIVATOR COMPLEX BLOCKED BY A 2- OR 4-AMINOBENZOYL GROUP; ANTICOAGULANT | BEECHAM GROUP P.L.C. (GB) | 1985-03-26 | — | — | US | disclosed |
| WO-1985000521-A1 | ENZYME DERIVATIVES | BEECHAM GROUP P.L.C. (GB) | 1985-02-14 | — | — | WO | disclosed |
| EP-0125269-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1984-11-21 | — | — | EP | disclosed |
| WO-1984001960-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | BEECHAM GROUP PLC (GB) | 1984-05-24 | — | — | WO | disclosed |
| EP-0091240-A2 | Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1983-10-12 | — | — | EP | disclosed |
| US-3970608-A | Epoxidized acetylene-conjugated diene random copolymer and the curable composition comprising the same | BRIDGESTONE TIRE COMPANY LIMITED (JA) | 1976-07-20 | — | — | US | disclosed |