Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.33 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9345631 | 0.85 | MMP2 (0.34) | MMP2MMP9ITGB3ITGA2BGNAI3 | |
| Isonipecotic Acid SCHEMBL9344171 | 0.80 | GABRA5 (0.50) | MMP2MMP9ITGB3ITGA2BGABRP | |
| SCHEMBL8259490 | 0.79 | MMP2 (0.38) | MMP2MMP9ITGB3ITGA2BTPSAB1 | |
| SCHEMBL9349025 | 0.77 | MMP2 (0.36) | MMP2MMP9 | |
| SCHEMBL9345623 | 0.75 | GABRP (0.38) | MMP2MMP9ITGB3ITGA2BGNAI3 | |
| SCHEMBL9344314 | 0.74 | MMP2 (0.34) | MMP2MMP9 | |
| Glycine SCHEMBL9349017 | 0.74 | ITGB3 (0.37) | MMP2MMP9ITGB3ITGA2BF2R | |
| SCHEMBL27722474 | 0.74 | GABRP (0.42) | ITGB3ITGA2BF2RGABRPGABRD | |
| SCHEMBL28403953 | 0.74 | GABRA1 (0.45) | ITGB3ITGA2BGABRPGABRDGABRA1 | |
| SCHEMBL9348788 | 0.73 | MMP2 (0.34) | MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5280031-A | Cyclic azaaliphatic compounds with a nitroxy function, processes for the preparation thereof and pharmaceutical compositions containing them | BOEHRINGER MANNHEIM GMBH (DE) | 1994-01-18 | — | — | US | disclosed |
| US-5030641-A | Treatment of angina pectoris, hypotensive agents | BOEHRINGER MANNHEIM GMBH (DE) | 1991-07-09 | — | — | US | disclosed |