SCHEMBL9345894

SCHEMBL9345894

O=S(=O)(Nc1ccc(O)c(NS(=O)(=O)c2ccccc2)c1)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 1.00
GFER P55789 1/20 1.00
APOBEC3G Q9HC16 1/20 1.00
LMNA P02545 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
ALDH1A1 P00352 2/20 0.58
HTT P42858 2/20 0.58
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
PKM P14618 1/20 0.58
CRHBP P24387 1/20 0.57
CRHR2 Q13324 1/20 0.57
HSP90AA1 P07900 2/20 0.57
HSP90AB1 P08238 2/20 0.57
ERBB2 P04626 1/20 0.56
KEAP1 Q14145 2/20 0.56
IL1RN P18510 1/20 0.56
ERAP1 Q9NZ08 1/20 0.56
CA12 O43570 1/20 0.56
CA1 P00915 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27834945 0.89 GAA (0.80) GAAGFERAPOBEC3GLMNASMN1; SMN2
SCHEMBL23226682 0.85 STING1 (0.77) GAAGFERAPOBEC3GLMNAALDH1A1
SCHEMBL23226678 0.83 GAA (0.70) GAAGFERAPOBEC3GHTTMEN1
SCHEMBL6802646 0.82 ERBB2 (0.77) GAAGFERAPOBEC3GLMNAALDH1A1
SCHEMBL12840705 0.82 GAA (0.69) GAAGFERAPOBEC3GLMNAALDH1A1
SCHEMBL7523467 0.82 HSD17B3 (0.73) GAAGFERAPOBEC3GLMNASMN1; SMN2
SCHEMBL8016507 0.82 GAA (0.69) GAAGFERAPOBEC3GLMNASMN1; SMN2
SCHEMBL13997280 0.82 CYTH2 (0.71) GAAGFERAPOBEC3GLMNASMN1; SMN2
SCHEMBL9345893 0.81 GAA (0.69) GAAGFERAPOBEC3GLMNASMN1; SMN2
SCHEMBL16366458 0.81 ALDH1A1 (0.75) GAAGFERAPOBEC3GLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8962244-B2 Compounds for modulating RNA binding proteins and uses therefor UNIVERSITY OF MASSACHUSETTS (US) 2015-02-24 US disclosed
US-8962244-B2 Compounds for modulating RNA binding proteins and uses therefor UNIVERSITY OF MASSACHUSETTS (US) 2015-02-24 US disclosed
US-20130217685-A1 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR UNIVERSITY OF MASSACHUSETTS (US) 2013-08-22 US disclosed
US-20130217685-A1 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR UNIVERSITY OF MASSACHUSETTS (US) 2013-08-22 US disclosed
US-8377639-B2 Compounds for modulating RNA binding proteins and uses therefor UNIVERSITY OF MASSACHUSETTS (US) 2013-02-19 US disclosed
US-8377639-B2 Compounds for modulating RNA binding proteins and uses therefor UNIVERSITY OF MASSACHUSETTS (US) 2013-02-19 US disclosed
US-20110065704-A1 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-03-17 US disclosed
US-20110065704-A1 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2011-03-17 US disclosed
WO-2010151797-A2 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR UNIVERSITY OF MASSACHUSETTS (US) 2010-12-29 WO disclosed
EP-0284081-B1 Silver halide photographic material FUJI PHOTO FILM CO LTD (JP) 1994-08-10 EP disclosed
EP-0280330-B1 SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL FUJI PHOTO FILM CO., LTD. (JP) 1993-07-21 EP disclosed
EP-0283938-B1 SILVER HALIDE COLOR PHOTOGRAPHIC MATERIAL Fuji Photo Film Co., Ltd. (JP) 1992-08-26 EP disclosed
US-4960688-A CONTAINING WATER SOLUBLE POLYMER FUJI PHOTO FILM CO., LTD. (JP) 1990-10-02 US disclosed
US-4946771-A POLYMERIC COUPLERS; SHARPNESS, PREVENT MIXING OF COLORS FUJI PHOTO FILM CO., LTD. (JP) 1990-08-07 US disclosed
US-4874689-A POLYMER COUPLER; CHAIN TRANSFER AGENT FUJI PHOTO FILM CO., LTD. (JP) 1989-10-17 US disclosed
EP-0316955-A2 Silver halide color photographic materials FUJI PHOTO FILM CO., LTD. (JP) 1989-05-24 EP disclosed
EP-0284081-A2 Silver halide photographic material FUJI PHOTO FILM CO., LTD. (JP) 1988-09-28 EP disclosed
EP-0283938-A1 Silver halide color photographic material Fuji Photo Film Co., Ltd. (JP) 1988-09-28 EP disclosed
EP-0280330-A2 Silver halide color photographic material FUJI PHOTO FILM CO., LTD. (JP) 1988-08-31 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130217685-A1 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR TIA1, ZFP3, RBM3 GAA 3022/4885GFER 3541/4885APOBEC3G 2006/4885
US-20110065704-A1 COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR TIA1, ZFP3, RBM3 GAA 3022/4885GFER 3541/4885APOBEC3G 2006/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.