Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.39 |
| ▸ | HTR3B | O95264 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127233 | 0.81 | TRPV4 (0.55) | SLC6A4SLC6A2SLC6A3KCNH2TRPV4 | |
| SCHEMBL29636402 | 0.81 | TRPV4 (0.55) | SLC6A4SLC6A2SLC6A3KCNH2TRPV4 | |
| SCHEMBL20130814 | 0.80 | PDE4A (0.47) | KDM4EALDH1A1TP53MEN1KMT2A | |
| SCHEMBL28298273 | 0.79 | TRPV4 (0.53) | SLC6A4SLC6A2SLC6A3KCNH2TRPV4 | |
| SCHEMBL9348336 | 0.78 | TSHR (0.45) | SLC6A4SLC6A2SLC6A3KDM4EALDH1A1 | |
| SCHEMBL9351955 | 0.78 | SLC6A3 (0.47) | SLC6A4SLC6A2SLC6A3KCNH2KDM4E | |
| SCHEMBL17780120 | 0.76 | CYP1A1 (0.61) | ALDH1A1TTR | |
| SCHEMBL17780115 | 0.76 | CYP19A1 (0.56) | KDM4E | |
| SCHEMBL17780121 | 0.76 | CYP1A1 (0.61) | ALDH1A1TTR | |
| SCHEMBL29615609 | 0.74 | ALDH1A1 (0.61) | SLC6A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0271833-B1 | Process for the preparation of aminopyrimidines | HOECHST SCHERING AGREVO GMBH (DE) | 1994-09-07 | — | — | EP | disclosed |
| US-4831138-A | FROM PROPANEDIIMIDATES DERIVATIVES AND CYANURATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0271833-A2 | Process for the preparation of aminopyrimidines | Hoechst Schering AgrEvo GmbH (DE) | 1988-06-22 | — | — | EP | disclosed |