Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | CCR1 | P32246 | 2/20 | 0.59 |
| ▸ | CCR5 | P51681 | 2/20 | 0.59 |
| ▸ | CCR8 | P51685 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.59 |
| ▸ | ALPL | P05186 | 1/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.59 |
| ▸ | ALPG | P10696 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | METAP1 | P53582 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29074210 | 0.87 | LMNA (0.45) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL9792961 | 0.87 | PIM1 (0.50) | KDM4ELMNAALOX15TDP1 | |
| SCHEMBL4811257 | 0.84 | LMNA (0.62) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL3165743 | 0.82 | ALDH1A1 (0.63) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL5997996 | 0.82 | KDM4E (0.59) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL27873934 | 0.81 | P2RX7 (0.54) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL20412771 | 0.81 | KMT2A (0.68) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL6646668 | 0.79 | KDM4E (0.50) | KDM4ELMNAL3MBTL1CCR1CCR5 | |
| SCHEMBL1505348 | 0.78 | — | — | |
| SCHEMBL4914089 | 0.78 | CES2 (0.67) | KDM4ELMNAL3MBTL1MAPK1P4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108383779-B | Preparation method of 3 '-aryl-2, 2' -bipyridine-6-formamide derivative | 华侨大学 | 2021-02-02 | — | — | CN | claimed |
| CN-108383779-A | A kind of preparation method of 3 '-aryl-bipy 2,2' bipyridyl -6- carboxamides derivatives | 华侨大学 | 2018-08-10 | — | — | CN | claimed |
| US-8378108-B2 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2013-02-19 | — | — | US | claimed |
| CN-116751195-B | Bipyridine compound, pharmaceutically acceptable salt thereof, preparation method and application | 杭州科兴生物化工有限公司 | 2025-03-07 | — | — | CN | disclosed |
| WO-2024199524-A1 | COMPOUND AS PKMYT1 INHIBITOR | 江苏星盛新辉医药有限公司 | 2024-10-03 | — | — | WO | disclosed |
| CN-116891456-A | Heterocyclic derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-10-17 | — | — | CN | disclosed |
| CN-116751195-A | Bipyridine compound, pharmaceutically acceptable salt thereof, preparation method and application | 杭州科兴生物化工有限公司 | 2023-09-15 | — | — | CN | disclosed |
| CN-110078661-B | Preparation method of 3-alkenyl-2, 2' -bipyridine-6-formamide derivative | 华侨大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-110078661-B | Preparation method of 3-alkenyl-2, 2' -bipyridine-6-formamide derivative | 华侨大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-110078662-B | Preparation method of 3-acyl methyl-2, 2' -bipyridine-6-formamide derivative | 华侨大学 | 2022-03-04 | — | — | CN | disclosed |
| CN-108383779-B | Preparation method of 3 '-aryl-2, 2' -bipyridine-6-formamide derivative | 华侨大学 | 2021-02-02 | — | — | CN | disclosed |
| CN-110078662-A | A kind of preparation method of 3- acyl methyl-bipy 2,2' bipyridyl -6- carboxamides derivatives | 华侨大学 | 2019-08-02 | — | — | CN | disclosed |
| CN-108383779-A | A kind of preparation method of 3 '-aryl-bipy 2,2' bipyridyl -6- carboxamides derivatives | 华侨大学 | 2018-08-10 | — | — | CN | disclosed |
| CN-108383779-A | A kind of preparation method of 3 '-aryl-bipy 2,2' bipyridyl -6- carboxamides derivatives | 华侨大学 | 2018-08-10 | — | — | CN | disclosed |
| EP-2681197-A1 | TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012120415-A1 | TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |
| EP-2344474-A1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | Novartis AG (CH) | 2011-07-20 | — | — | EP | disclosed |
| WO-2011008709-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-20 | — | — | WO | disclosed |
| WO-2010026124-A1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | HRH3, HRH4, HRH1 | KDM4E 488/4885LMNA 3210/4885L3MBTL1 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.