Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F12 | P00748 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28938168 | 0.76 | ELANE (0.42) | NOS1FBP1ELANEPDE4BF2 | |
| SCHEMBL135362 | 0.76 | ELANE (0.60) | ELANEPDE4BF2PLAUKLKB1 | |
| SCHEMBL16572100 | 0.74 | RAB9A (0.44) | NOS1ELANEPDE4BF2PLAU | |
| SCHEMBL11234147 | 0.73 | ELANE (0.40) | NOS1FBP1ELANEPDE4BF2 | |
| SCHEMBL11234150 | 0.73 | ELANE (0.40) | NOS1FBP1ELANEPDE4BF2 | |
| SCHEMBL14936408 | 0.71 | NOS1 (0.65) | NOS1FBP1ELANEF2PLAU | |
| SCHEMBL5378534 | 0.69 | — | — | |
| SCHEMBL27651206 | 0.68 | FBP1 (0.53) | NOS1FBP1ELANEPDE4B | |
| Hydrochloric Acid SCHEMBL6503814 | 0.67 | ALOX12 (0.41) | NOS1PDE4BALDH1A1TSHRMAPT | |
| SCHEMBL31340016 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0293220-B1 | Pharmacologically active 2-and 3-substituted (1', 5'-diaryl-3-pyrazolyl)-N-Hydroxypropanamides and method for synthesizing | ORTHO PHARMA CORP (US) | 1994-08-31 | — | — | EP | disclosed |
| EP-0248594-B1 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMA CORP (US) | 1993-11-24 | — | — | EP | disclosed |
| US-5242940-A | Antiinflammatory agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |
| US-5164381-A | Cardiovascular, antiinflammatory | ORTHO PHARMACEUTICAL CORPORATION (US) | 1992-11-17 | — | — | US | disclosed |
| US-5051518-A | Antiinflammatory agents and cardiovascular disorders | ORTHO PHARMACEUTICAL CORPORATION (US) | 1991-09-24 | — | — | US | disclosed |
| US-4826868-A | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use | ORTHO PHARMACEUTICAL CORPORATION (US) | 1989-05-02 | — | — | US | disclosed |
| EP-0293220-A2 | Pharmacologically active 2-and 3-substituted (1', 5'-diaryl-3-pyrazolyl)-N-Hydroxypropanamides and method for synthesizing | ORTHO PHARMACEUTICAL CORPORATION (US) | 1988-11-30 | — | — | EP | disclosed |
| EP-0248594-A2 | Pharmacologically active 1,5-diaryl-3-substituted-pyrazoles and method for synthesizing the same | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-12-09 | — | — | EP | disclosed |