Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.58 |
| ▸ | CA2 | P00918 | 10/20 | 0.58 |
| ▸ | CA7 | P43166 | 4/20 | 0.58 |
| ▸ | CA9 | Q16790 | 4/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.58 |
| ▸ | CA12 | O43570 | 3/20 | 0.58 |
| ▸ | CA3 | P07451 | 3/20 | 0.58 |
| ▸ | CA4 | P22748 | 3/20 | 0.58 |
| ▸ | CA6 | P23280 | 3/20 | 0.58 |
| ▸ | CA5A | P35218 | 3/20 | 0.58 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.58 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | HTT | P42858 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzenesulfonamide SCHEMBL16238901 | 0.79 | CA1 (0.56) | CA1CA2CA7CA9CA14 | |
| SCHEMBL9352629 | 0.78 | CA1 (0.65) | CA1CA2CA7CA9CA14 | |
| SCHEMBL14907228 | 0.78 | LIPE (0.66) | SMN1; SMN2ALDH1A1GAALMNAKDM4E | |
| SCHEMBL9352647 | 0.78 | CA1 (0.61) | CA1CA2CA7CA9CA14 | |
| Zidapamide SCHEMBL2109204 | 0.75 | CA1 (0.63) | CA1CA2CA7CA9CA14 | |
| SCHEMBL14890641 | 0.75 | LIPE (0.62) | SMN1; SMN2ALDH1A1RAB9ANPC1HTT | |
| SCHEMBL10773489 | 0.74 | SMN1; SMN2 (0.56) | CA1CA2CA7CA9CA14 | |
| Indapamide SCHEMBL476213 | 0.73 | CA1 (1.00) | CA1CA2CA7CA9CA14 | |
| Indapamide SCHEMBL29372690 | 0.73 | CA1 (1.00) | CA1CA2CA7CA9CA14 | |
| Indapamide SCHEMBL41303 | 0.73 | CA1 (1.00) | CA1CA2CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0324184-B1 | 2-Amino-1,2,3,4-tetrahydroisoquinoline derivatives, method for their preparation and their use as medicines | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1994-09-28 | — | — | EP | claimed |
| US-4940716-A | 2-amino-tetrahydro-isoquinolene derivatives and a process for the preparation thereof and pharmaceutical compositions containing same | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1990-07-10 | — | — | US | claimed |
| EP-0324184-A2 | 2-Amino-1,2,3,4-tetrahydroisoquinoline derivatives, method for their preparation and their use as medicines | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-07-19 | — | — | EP | claimed |
| JP-1213266-A | — | — | None | — | — | JP | disclosed |
| EP-0324184-B1 | 2-Amino-1,2,3,4-tetrahydroisoquinoline derivatives, method for their preparation and their use as medicines | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1994-09-28 | — | — | EP | disclosed |
| US-4940716-A | 2-amino-tetrahydro-isoquinolene derivatives and a process for the preparation thereof and pharmaceutical compositions containing same | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1990-07-10 | — | — | US | disclosed |
| JP-H01213266-A | 2-AMINO-TETRAHYDRO-ISOQUINOLINE DERIVATIVE, ITS PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | CHINOIN GYOGYSZER V T G RT | 1989-08-28 | — | — | JP | disclosed |
| EP-0324184-A2 | 2-Amino-1,2,3,4-tetrahydroisoquinoline derivatives, method for their preparation and their use as medicines | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-07-19 | — | — | EP | disclosed |