Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.58 |
| ▸ | MLNR | O43193 | 1/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | CNR1 | P21554 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | NPY1R | P25929 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007025 | 1.00 | HTR1A (0.58) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| SCHEMBL7992903 | 1.00 | HTR1A (0.58) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| Hydrochloric Acid SCHEMBL16340249 | 0.98 | HTR1A (0.57) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| Hydrochloric Acid SCHEMBL2248981 | 0.98 | HTR1A (0.57) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| Formic Acid SCHEMBL28804070 | 0.93 | HTR1A (0.55) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| SCHEMBL6856918 | 0.88 | HTR1A (0.52) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| SCHEMBL14681243 | 0.88 | HTR1A (0.52) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| SCHEMBL6856896 | 0.88 | HTR1A (0.52) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| SCHEMBL1041687 | 0.87 | DRD2 (0.45) | HTR1AMLNRADRB2ADRB1ADRA2A | |
| SCHEMBL4932628 | 0.85 | HTR1A (0.52) | HTR1AMLNRADRB2ADRB1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102816141-A | Method for preparing nebivolol racemate hydrochloride | JINAN ASIA PHARMA TECH CO LTD | 2012-12-12 | — | — | CN | claimed |
| WO-2010089764-A2 | IMPROVED PROCESS FOR THE PREPARATION OF NEBIVOLOL HYDROCHLORIDE | MSN LABORATORIES LIMITED (IN) | 2010-08-12 | — | — | WO | claimed |
| CN-101020682-A | Synthesis process of 6-fluoro-3, 4-dihydro-2H-1-benzopyran-2-formaldehyde | UNIV ZHEJIANG (CN) | 2007-08-22 | — | — | CN | claimed |
| CN-101020681-A | Synthesis process of 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol | UNIV ZHEJIANG (CN) | 2007-08-22 | — | — | CN | claimed |
| US-20070021623-A1 | Novel process for preparation of nebivolol intermediates | HETERO DRUGS LIMITED (IN) | 2007-01-25 | — | — | US | claimed |
| EP-0334429-A1 | Agents for lowering the blood pressure | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-09-27 | — | — | EP | claimed |
| CN-110305099-B | Preparation and application of nebivolol-based Smo inhibitor | 东南大学 | 2022-11-29 | — | — | CN | disclosed |
| CN-106317006-A | Preparation method of 6-fluorochromane-2-formaldehyde as nebivolol intermediate | 陕西思尔生物科技有限公司 | 2017-01-11 | — | — | CN | disclosed |
| WO-2016185492-A1 | PROCESS FOR PREPARATION OF NEBIVOLOL AND IT'S SALTS | IPCA LABORATORIES LIMITED (IN) | 2016-11-24 | — | — | WO | disclosed |
| EP-2265596-B1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM SPA (IT) | 2016-06-01 | — | — | EP | disclosed |
| CN-102186835-B | Process for preparing nebivolol | ZACH SYSTEM S.P.A. (IT) | 2016-01-13 | — | — | CN | disclosed |
| EP-2528905-B1 | PROCESS FOR THE PREPARATION OF NEBIVOLOL | CORDEN PHARMA COLORADO INC (US) | 2015-10-07 | — | — | EP | disclosed |
| EP-2346845-B1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM SPA (IT) | 2015-03-25 | — | — | EP | disclosed |
| US-5824682-A | Vasoconstrictive dihydrobenzopyran derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-10-20 | — | — | US | disclosed |
| EP-0714396-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-06-05 | — | — | EP | disclosed |
| WO-1995005383-A1 | VASOCONTRICTIVE DIHYDROBENZOPYRAN DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-02-23 | — | — | WO | disclosed |
| EP-0334429-A1 | Agents for lowering the blood pressure | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-09-27 | — | — | EP | disclosed |
| EP-0145067-B1 | DERIVATIVES OF 2,2'-IMINOBISETHANOL | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-25 | — | — | EP | disclosed |
| US-4654362-A | CARDIOVASCULAR DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-03-31 | — | — | US | disclosed |
| EP-0145067-A2 | Derivatives of 2,2'-iminobisethanol | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021623-A1 | Novel process for preparation of nebivolol intermediates | ADRB2, ADRB1, ADRA1D | HTR1A 94/4885MLNR 85/4885ADRB2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.