SCHEMBL9355285

SCHEMBL9355285

CC=C(C)C[SiH](c1ccccc1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.37
TRPA1 O75762 1/20 0.33
ATM Q13315 1/20 0.30
KDM4E B2RXH2 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9355276 1.00 MAPT (0.37) MAPTTRPA1ATMKDM4ETDP1
SCHEMBL8858240 0.76 LMNA (0.31)
SCHEMBL10862351 0.76 ALDH1A1 (0.43) MAPTKDM4ETDP1
SCHEMBL9354787 0.71 TRPV1 (0.36) MAPTTRPA1ATMKDM4E
SCHEMBL9354779 0.71 TRPV1 (0.36) MAPTTRPA1ATMKDM4E
SCHEMBL30610275 0.70 LMNA (0.36) MAPTATMKDM4E
SCHEMBL5383301 0.68 MAOA (0.30)
SCHEMBL6746849 0.67 SLC6A3 (0.43) MAPTATMKDM4ETDP1
SCHEMBL9305085 0.67 MAOB (0.32)
SCHEMBL10707618 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0460240-B1 CATALYST FOR HYDROGENATION, DEHYDROSILYLATION OR HYDROSILYLATION, AND ITS USE SAGAMI CHEM RES (JP) 1994-11-09 EP disclosed
US-5182246-A Complex metal carbonyl SAGAMI CHEMICAL RESEARCH CENTER (JP) 1993-01-26 US disclosed
EP-0460240-A1 CATALYST FOR HYDROGENATION, DEHYDROSILYLATION OR HYDROSILYLATION, AND ITS USE SAGAMI CHEMICAL RESEARCH CENTER (JP) 1991-12-11 EP disclosed