Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9359494 | 0.72 | TERT (0.37) | TERTSTAT3HIF1AHTR1ADRD2 | |
| SCHEMBL10581343 | 0.71 | HTR1A (0.50) | CHRM2CHRM3TERTSCN1ASCN2A | |
| SCHEMBL9355929 | 0.70 | CHRM2 (0.43) | CHRM2CHRM3SCN1ASCN2ASCN3A | |
| SCHEMBL10426634 | 0.66 | TERT (0.52) | CHRM2CHRM3TERTSCN1ASCN2A | |
| SCHEMBL9356154 | 0.66 | CHRM2 (0.44) | CHRM2CHRM3ADRA1A | |
| SCHEMBL17147302 | 0.65 | CHRM2 (0.78) | CHRM2CHRM3ADRA1ACYP19A1 | |
| SCHEMBL14359467 | 0.65 | CHRM2 (0.46) | CHRM2CHRM3HIF1AHRH1CYP2D6 | |
| SCHEMBL14359787 | 0.64 | CHRM2 (0.45) | CHRM2CHRM3HIF1AHRH1CYP2D6 | |
| SCHEMBL9437755 | 0.64 | CHRM2 (0.45) | CHRM2CHRM3SCN1ASCN2ASCN3A | |
| SCHEMBL14359411 | 0.64 | CHRM2 (0.45) | CHRM2CHRM3HIF1AHRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310321-B1 | Immunomodulatory azaspiranes | SMITHKLINE BEECHAM CORP (US) | 1994-11-30 | — | — | EP | disclosed |
| WO-1989002889-A1 | IMMUNOMODULATORY AZASPIRANES | SMITHKLINE BECKMAN CORPORATION (US) | 1989-04-06 | — | — | WO | disclosed |
| EP-0310321-A2 | Immunomodulatory azaspiranes | SMITHKLINE BEECHAM CORPORATION (US) | 1989-04-05 | — | — | EP | disclosed |