Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 6/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 4/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10440186 | 0.86 | PNMT (0.33) | PNMTDRD2DRD3PTGS2MALT1 | |
| SCHEMBL8688431 | 0.77 | TDP1 (0.51) | PNMTDRD2DRD3ABCB1 | |
| SCHEMBL908349 | 0.75 | DRD2 (0.38) | DRD2DRD3DPP4 | |
| SCHEMBL31006601 | 0.73 | PNMT (0.48) | PNMTDRD2DRD3DPP4PTGS2 | |
| SCHEMBL5133781 | 0.72 | CHRM2 (0.45) | — | |
| Water SCHEMBL167691 | 0.72 | CHRM2 (0.45) | — | |
| SCHEMBL2152471 | 0.71 | POLB (0.45) | DRD2DRD3PTGS2MALT1ABCB1 | |
| SCHEMBL8899294 | 0.71 | PNMT (0.37) | PNMTDRD2DRD3DPP4PTGS2 | |
| SCHEMBL8996648 | 0.70 | HRH3 (0.39) | PNMTDRD2DRD3 | |
| SCHEMBL36938 | 0.70 | CHRM2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126367-B1 | Chroman and chromene derivatives | BEECHAM GROUP PLC (GB) | 1994-10-12 | — | — | EP | disclosed |
| US-4575511-A | Anti-hypertensive chromanol derivatives | BEECHAM GROUP P.L.C. (GB) | 1986-03-11 | — | — | US | disclosed |
| EP-0126367-A1 | Chroman and chromene derivatives | BEECHAM GROUP PLC (GB) | 1984-11-28 | — | — | EP | disclosed |