Water

Water

SCHEMBL167691

O.c1ccc2c(c1)CC1OC1O2

nearest known ligand 0.45

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 2/20 0.45
CHRM4 known ✓ P08173 2/20 0.45
CHRM5 known ✓ P08912 2/20 0.45
CHRM1 known ✓ P11229 2/20 0.45
CHRM3 known ✓ P20309 2/20 0.45
HDAC3 known ✓ O15379 1/20 0.34
HDAC4 known ✓ P56524 1/20 0.34
HDAC1 known ✓ Q13547 1/20 0.34
HDAC7 known ✓ Q8WUI4 1/20 0.34
HDAC2 known ✓ Q92769 1/20 0.34
HDAC10 known ✓ Q969S8 1/20 0.34
HDAC11 known ✓ Q96DB2 1/20 0.34
HDAC8 known ✓ Q9BY41 1/20 0.34
HDAC6 known ✓ Q9UBN7 1/20 0.34
HDAC9 known ✓ Q9UKV0 1/20 0.34
HDAC5 known ✓ Q9UQL6 1/20 0.34
ADORA3 known ✓ P0DMS8 1/20 0.33
MAOB P27338 7/20 0.38
MAOA P21397 6/20 0.38
AOC2 O75106 5/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL36938 0.98 CHRM2 (0.46) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL162329 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL22583920 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
Fluoride SCHEMBL5670739 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL10699051 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL25424228 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL5133781 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL1286412 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL4560444 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL1058867 0.96 CHRM2 (0.45) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 446 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210301123-A1 EXTRUSION PROFILE FOR A DOOR COMPONENT AND/OR WINDOW COMPONENT AS WELL AS A MANUFACTURING METHOD SALAMANDER INDUSTRIE-PRODUKTE GMBH (DE) 2021-09-30 US claimed
EP-2188669-B1 ELECTROFLUIDIC DEVICES, VISUAL DISPLAYS, AND METHODS FOR MAKING AND OPERATING SUCH ELECTROFLUIDIC DEVICES UNIV CINCINNATI (US) 2017-01-11 EP claimed
US-20150118494-A1 SURFACE MODIFIED PIGMENT PARTICLES, METHOD OF PREPARATION & APPLICATION THEREOF SUN CHEMICAL CORPORATION 2015-04-30 US claimed
EP-2847279-A1 SURFACE MODIFIED PIGMENT PARTICLES, METHOD OF PREPARATION AND APPLICATION THEREOF Sun Chemical Corporation (US) 2015-03-18 EP claimed
WO-2013169395-A1 SURFACE MODIFIED PIGMENT PARTICLES, METHOD OF PREPARATION AND APPLICATION THEREOF SUN CHEMICAL CORPORATION (US) 2013-11-14 WO claimed
US-8111465-B2 Electrofluidic devices, visual displays, and methods for making and operating such electrofluidic devices UNIVERSITY OF CINCINNATI (US) 2012-02-07 US claimed
EP-1562534-B1 COSMETIC DRESSINGS CONTAINING A WAXY COMPONENT, A FILM-FORMING AGENT AND A GEL-FORMING SUBSTANCE SCHWAN STABILO COSMETICS GMBH (DE) 2010-09-22 EP claimed
US-20100208328-A1 Electrofluidic Devices, Visual Displays, And Methods For Making And Operating Such Elecrofluidic Devices UNIVERSITY OF CINCINNATI (US) 2010-08-19 US claimed
EP-2188669-A1 ELECTROFLUIDIC DEVICES, VISUAL DISPLAYS, AND METHODS FOR MAKING AND OPERATING SUCH ELECTROFLUIDIC DEVICES University of Cincinnati (US) 2010-05-26 EP claimed
WO-2009036272-A1 ELECTROFLUIDIC DEVICES, VISUAL DISPLAYS, AND METHODS FOR MAKING AND OPERATING SUCH ELECTROFLUIDIC DEVICES UNIVERSITY OF CINCINNATI (US) 2009-03-19 WO claimed
WO-2003093372-A1 PIGMENT PREPARATIONS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-11-13 WO claimed
US-20030033958-A1 Easily distributable pigment compositions CIBA SPECIALITY CHEMICALS CORP. 2003-02-20 US claimed
EP-1277808-A2 Easily distributable pigment compositions Ciba SC Holding AG (CH) 2003-01-22 EP claimed
US-20020188051-A1 Coating with spectral selectivity CONSTRUCTION RESEARCH & TECHNOLOGY GMBH (DE) 2002-12-12 US claimed
US-6063182-A Stir-in pigment compositions CIBA SPECIALITY CHEMICALS CORPORATION (US) 2000-05-16 US claimed
US-5997627-A Pigment composition and effect coatings CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-12-07 US claimed
EP-0704560-B1 Stabilization of pigmented fiber with a synergistic mixture of hindered amine and UV absorber CIBA GEIGY AG (CH) 1999-01-13 EP claimed
EP-0842989-A2 Pigment compositions and effect coatings Ciba SC Holding AG (CH) 1998-05-20 EP claimed
EP-0704560-A1 Stabilization of pigmented fiber with a synergistic mixture of hindered amine and UV absorber CIBA-GEIGY AG (CH) 1996-04-03 EP claimed
US-4477608-A AND THERMOPLASTIC RESIN WITH ORGANIC OR INORGANIC PIGMENTS CIBA-GEIGY CORPORATION (US) 1984-10-16 US claimed