Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887689 | 0.78 | DRD2 (0.40) | DRD2HTR2AMLNRADRB2ADRB1 | |
| SCHEMBL9358376 | 0.75 | PNMT (0.36) | DRD2DRD3DPP4 | |
| SCHEMBL15724653 | 0.74 | TDP1 (0.56) | DRD2HTR2AMLNRADRB2ADRB1 | |
| SCHEMBL15749929 | 0.74 | TDP1 (0.56) | DRD2HTR2AMLNRADRB2ADRB1 | |
| SCHEMBL36938 | 0.73 | CHRM2 (0.46) | ADORA3CHRM1HRH3MAOB | |
| SCHEMBL25424228 | 0.72 | CHRM2 (0.45) | CHRM1HRH3MAOB | |
| SCHEMBL1286412 | 0.72 | CHRM2 (0.45) | ADORA3CHRM1HRH3MAOB | |
| SCHEMBL162329 | 0.72 | CHRM2 (0.45) | ADORA3CHRM1HRH3MAOB | |
| SCHEMBL22583920 | 0.72 | CHRM2 (0.45) | ADORA3CHRM1HRH3MAOB | |
| SCHEMBL10699051 | 0.72 | CHRM2 (0.45) | ADORA3CHRM1HRH3MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392361-B2 | Process for the synthesis of intermediates of Nebivolol | MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. (LU) | 2019-08-27 | — | — | US | disclosed |
| EP-2265596-B1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM SPA (IT) | 2016-06-01 | — | — | EP | disclosed |
| US-8981127-B2 | Method for preparing nebivolol | ZACH SYSTEM (FR) | 2015-03-17 | — | — | US | disclosed |
| US-8969597-B2 | Process for preparing nebivolol | ZACH SYSTEM S.P.A. (IT) | 2015-03-03 | — | — | US | disclosed |
| EP-2456768-B1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM SPA (IT) | 2014-11-19 | — | — | EP | disclosed |
| EP-2078005-B1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM SPA (IT) | 2013-05-08 | — | — | EP | disclosed |
| CN-101952270-B | Process for preparing nebivolol | ZACH SYSTEM SPA | 2013-04-24 | — | — | CN | disclosed |
| EP-2102196-B1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM SPA (IT) | 2012-08-01 | — | — | EP | disclosed |
| EP-2456768-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZaCh System S.p.A. (IT) | 2012-05-30 | — | — | EP | disclosed |
| CN-102471325-A | Process for preparing nebivolol | ZACH SYSTEM SPA | 2012-05-23 | — | — | CN | disclosed |
| EP-2265596-A2 | PROCESS FOR PREPARING NEBIVOLOL | ZaCh System S.p.A. (IT) | 2010-12-29 | — | — | EP | disclosed |
| US-20100076206-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2010-03-25 | — | — | US | disclosed |
| US-20100069652-A1 | The Process for Preparing Nebivolol | ZACH SYSTEM S.P.A. (IT) | 2010-03-18 | — | — | US | disclosed |
| WO-2009121710-A2 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2009-10-08 | — | — | WO | disclosed |
| EP-2102196-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZaCh System S.p.A. (IT) | 2009-09-23 | — | — | EP | disclosed |
| CN-101541791-A | Process for preparing nebivolol | ZACH SYSTEM SPA (IT) | 2009-09-23 | — | — | CN | disclosed |
| CN-101522656-A | Process for preparing nebivolol | ZACH SYSTEM SPA (IT) | 2009-09-02 | — | — | CN | disclosed |
| EP-2078005-A2 | PROCESS FOR PREPARING NEBIVOLOL | ZaCh System S.p.A. (IT) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008064826-A1 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008040528-A2 | PROCESS FOR PREPARING NEBIVOLOL | ZACH SYSTEM S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076206-A1 | PROCESS FOR PREPARING NEBIVOLOL | ADRB1, ADRB2, ADRA1B | DRD2 124/4885HTR2A 1102/4885MLNR 812/4885 |
| US-10392361-B2 | Process for the synthesis of intermediates of Nebivolol | ADRB3, ADRB2, ADRB1 | DRD2 388/4885HTR2A 658/4885MLNR 2010/4885 |
| US-20100069652-A1 | The Process for Preparing Nebivolol | CYP4A11, ADRB1, CYP4B1 | DRD2 377/4885HTR2A 743/4885MLNR 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.