Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 14/20 | 0.47 |
| ▸ | ACHE | P22303 | 14/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9358728 | 1.00 | BCHE (0.47) | BCHEACHEAPPMAOB | |
| Fumaric Acid SCHEMBL9358760 | 0.89 | BCHE (0.40) | BCHEACHEAPPMAOB | |
| Fumaric Acid SCHEMBL9358774 | 0.89 | BCHE (0.40) | BCHEACHEAPPMAOB | |
| Fumaric Acid SCHEMBL9358712 | 0.87 | ACHE (0.50) | BCHEACHEMAOB | |
| Fumaric Acid SCHEMBL9359036 | 0.87 | ACHE (0.50) | BCHEACHEMAOB | |
| SCHEMBL9362996 | 0.81 | ACHE (0.56) | BCHEACHEMAOB | |
| Hydrochloric Acid SCHEMBL9359043 | 0.79 | ACHE (0.54) | BCHEACHEAPPMAOB | |
| Fumaric Acid SCHEMBL9150672 | 0.77 | ACHE (0.60) | BCHEACHE | |
| Fumaric Acid SCHEMBL9150679 | 0.77 | ACHE (0.60) | BCHEACHE | |
| SCHEMBL9151835 | 0.72 | ACHE (0.66) | BCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0383318-B1 | Aralkylamine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5180746-A | Cholinesterase Inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-19 | — | — | US | disclosed |
| EP-0383318-A2 | Aralkylamine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-08-22 | — | — | EP | disclosed |