Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458604 | 0.79 | CYP2A6 (0.40) | CYP2A6CYP1A2LMNASMN1; SMN2MAP2K2 | |
| SCHEMBL9361125 | 0.78 | CYP2A6 (0.56) | CYP2A6LMNASMN1; SMN2MAP2K2MAP2K1 | |
| SCHEMBL30832956 | 0.77 | LMNA (0.57) | CYP2A6CYP1A2LMNASMN1; SMN2MAP2K2 | |
| SCHEMBL761802 | 0.77 | LMNA (0.57) | CYP2A6CYP1A2LMNASMN1; SMN2MAP2K2 | |
| SCHEMBL9458698 | 0.73 | CYP2A6 (0.46) | CYP2A6CYP1A2LMNASMN1; SMN2MAP2K2 | |
| SCHEMBL18518053 | 0.71 | CYP1A2 (0.52) | CYP2A6CYP1A2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL15207756 | 0.71 | MAOA (0.47) | CYP2A6LMNASMN1; SMN2HAO1MAPT | |
| SCHEMBL9458067 | 0.71 | PTGIR (0.35) | LMNASMN1; SMN2MAPTMAPK1KMT2A | |
| SCHEMBL3281214 | 0.71 | LMNA (0.52) | CYP2A6CYP1A2LMNASMN1; SMN2MAP2K2 | |
| SCHEMBL11300299 | 0.70 | ALDH1A1 (0.50) | CYP2A6CYP1A2LMNASMN1; SMN2MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409412-B1 | Diaryl ether cyclic ethers | ICI PLC (GB) | 1994-07-20 | — | — | EP | disclosed |
| EP-0409414-B1 | DIARYL ETHER CYCLOALKANES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-09-29 | — | — | EP | disclosed |
| US-5214070-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-05-25 | — | — | US | disclosed |
| US-5208259-A | Lipoxygenase enzyme inhibitors | IMPERIAL CHEMICAL INDUSTRIES (GB) | 1993-05-04 | — | — | US | disclosed |
| US-5137913-A | Inhibitors of the enzyme 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-08-11 | — | — | US | disclosed |
| EP-0409413-A2 | Diaryl ether heterocycles | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-23 | — | — | EP | disclosed |
| EP-0409414-A1 | Diaryl ether cycloalkanes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-23 | — | — | EP | disclosed |
| EP-0409412-A2 | Diaryl ether cyclic ethers | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-01-23 | — | — | EP | disclosed |