Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6042880 | 0.80 | KMT2A (0.45) | SMN1; SMN2LMNANPC1TLR9HTT | |
| SCHEMBL1442168 | 0.79 | MAPT (0.43) | SMN1; SMN2LMNANPC1TLR9HTT | |
| SCHEMBL5410660 | 0.76 | LRRK2 (0.41) | SMN1; SMN2LMNANPC1TLR9HTT | |
| SCHEMBL9362063 | 0.75 | NUDT1 (0.33) | LMNAFYNP2RX3P2RX2IDO1 | |
| SCHEMBL10999199 | 0.74 | MAPT (0.39) | SMN1; SMN2LMNANPC1TLR9HTT | |
| SCHEMBL20506972 | 0.73 | BRD4 (0.57) | L3MBTL1 | |
| SCHEMBL31366357 | 0.72 | ALDH1A1 (0.38) | SMN1; SMN2LMNATP53ALDH1A1HSD17B10 | |
| SCHEMBL2148581 | 0.72 | ALDH1A1 (0.38) | SMN1; SMN2LMNATP53ALDH1A1HSD17B10 | |
| SCHEMBL9045721 | 0.71 | P2RX3 (0.37) | SMN1; SMN2LMNATP53ALDH1A1MAPT | |
| SCHEMBL3169433 | 0.71 | FTO (0.40) | SMN1; SMN2TP53ALDH1A1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0392240-B1 | Esters of pyrimidine-4-yl-carbamidacid | BAYER AG (DE) | 1994-05-11 | — | — | EP | disclosed |
| US-5043337-A | Insecticidal pyrimidin-4-yl carbamates | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-27 | — | — | US | disclosed |
| EP-0392240-A1 | Esters of pyrimidine-4-yl-carbamidacid | BAYER AG (DE) | 1990-10-17 | — | — | EP | disclosed |